Hemophagocytic Lymphohistiocytosis Secondary to Melioidosis in Paediatric Patients: A Case Series.

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S505259

Kecheng Wan, Yingjie Liu, Yuwen Chen, Song Sun, Hong Liang

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引用次数: 0

Abstract

Background: Melioidosis caused by Burkholderia pseudomallei manifests as a variety of infectious symptoms. However, hemophagocytic lymphohistiocytosis (HLH) secondary to bacteraemic melioidosis is rarely documented in the literature. We report a series of fatal cases of melioidosis combined with HLH in one Chinese family.

Case presentation: Three cases of melioidosis with HLH were reported in a family with three children, two boys aged 4 and 6 years and a 12-year-old girl. The most common clinical presentation was fever. A blood culture confirmed B. pseudomallei, and bone marrow aspiration revealed hemophagocytosis. Despite the administration of antibiotics, glucocorticoids and other treatments, all the patients died, and their deaths were attributed to HLH.

Conclusion: Melioidosis complicating HLH is rare in occurrence, but the mortality rate is high. Clinicians should be aware of the risk of a B. pseudomallei bloodstream infection in children.

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儿童嗜血球性淋巴组织细胞病继发于类鼻疽：一个病例系列。

背景：假马利氏伯克氏菌引起的类鼻疽病表现为多种感染症状。然而，嗜血球性淋巴组织细胞增多症（HLH）继发于细菌性类鼻疽病在文献中很少有记载。我们报告一个中国家庭的类鼻疽合并HLH的一系列死亡病例。病例介绍：在一个有三个孩子的家庭中报告了三例类鼻疽伴HLH，两个4岁和6岁的男孩和一个12岁的女孩。最常见的临床表现为发热。血培养证实为假芽孢杆菌，骨髓穿刺显示噬血症。尽管给予了抗生素、糖皮质激素和其他治疗，但所有患者都死亡，他们的死亡归因于HLH。结论：类鼻疽合并HLH发生率低，但死亡率高。临床医生应该意识到儿童假芽孢杆菌血液感染的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.