Profiling chronic migraine patients according to clinical characteristics: a cluster analysis approach.

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

Frontiers in Neurology Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI:10.3389/fneur.2025.1569333

Masahito Katsuki, Yasuhiko Matsumori, Shin Kawamura, Kenta Kashiwagi, Akihito Koh, Tetsuya Goto, Kazuma Kaneko, Naomichi Wada, Fuminori Yamagishi

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Abstract

Background: To group the characteristics of chronic migraine (CM) by headache characteristics.

Methods: We performed a retrospective analysis of the medical records of 821 adult CM patients who visited a specialized outpatient clinic for headaches. Using the headache characteristics, we performed Density-Based Spatial Clustering of Applications with Noise (DBSCAN) clustering to group CM patients. The burdens to their lives, monthly headache days (MHD), monthly acute medication intake days (AMD), and treatment outcomes were evaluated among the clusters.

Results: Through a cluster analysis based on headache characteristics, our findings indicated the potential existence of three distinct types of CM: cluster 1 (predominantly female with CM resembling migraine), cluster 2 (higher age, higher BMI, smoker), and cluster 3 (mostly female with CM that have fewer migraine characteristics). The impact on quality of life was significant in cluster 1 compared to cluster 3. However, there were no differences in treatment outcomes, initial MHD, AMD, the years of migraine, or treatment sensitivity among these three clusters.

Conclusion: Cluster analysis mathematically divided CM patients into three groups, with predominant differences in the degree of disruption to their lives and their characteristics; further research is needed on the diagnostic criteria for CM and its characteristics.

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根据临床特征分析慢性偏头痛患者：聚类分析方法。

背景：对慢性偏头痛（CM）患者的头痛特征进行分组。方法：回顾性分析821例因头痛就诊的CM患者的病历。利用头痛特征，我们对CM患者进行了基于密度的噪声应用空间聚类（DBSCAN）聚类。评估各组患者的生活负担、每月头痛天数（MHD）、每月急性药物摄入天数（AMD）及治疗效果。结果：通过基于头痛特征的聚类分析，我们的发现表明可能存在三种不同类型的CM：第一类（主要是女性，CM类似于偏头痛），第二类（年龄较大，BMI较高，吸烟者）和第三类（主要是女性，CM具有较少的偏头痛特征）。与第3类相比，第1类对生活质量的影响显著。然而，这三组患者在治疗结果、初始MHD、AMD、偏头痛年数或治疗敏感性方面没有差异。结论：聚类分析将CM患者分为三组，在生活受干扰程度和特征上存在显著差异；CM的诊断标准及其特点有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neurology CLINICAL NEUROLOGYNEUROSCIENCES -NEUROSCIENCES

CiteScore

4.90

自引率

8.80%

发文量

2792

审稿时长

14 weeks

期刊介绍： The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.