Antidiabetic protolimonoids from the bark of Entandrophragma angolense

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-03-22 DOI:10.1016/j.fitote.2025.106487

Binh T.D. Trinh , Nhung T.H. Nguyen , Ngoc T.N. Ngo , Ly T.T. Nguyen , Lien-Hoa D. Nguyen , Le-Thu T. Nguyen

引用次数: 0

Abstract

Three new protolimonoids, entandrophins A-C (1–3), together with two known compounds, methyl angolensate (4) and stigmas-4-en-3-one (5), were isolated from the bark of Entandrophragma angolense. Their structures were elucidated based on spectroscopic analyses, mainly 1D and 2D NMR spectral data. The compounds were evaluated for their cytotoxicity against HepG2 cells and α-glucosidase inhibitory activity. Compounds 1–4 displayed very weak activity against HepG2 cells but compounds 2 and 3 exhibited significant α-glucosidase inhibition with IC₅₀ values of 57.5 ± 1.5 and 32.5 ± 0.9 μM, respectively.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.