Severe acute kidney injury with anuria induced by hypokalemia requiring hemodialysis: a case study.

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Seong-Wook Lee, Man-Hoon Han, Mee-Seon Kim, Yong-Jin Kim, You Hyun Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jeong-Hoon Lim
{"title":"Severe acute kidney injury with anuria induced by hypokalemia requiring hemodialysis: a case study.","authors":"Seong-Wook Lee, Man-Hoon Han, Mee-Seon Kim, Yong-Jin Kim, You Hyun Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jeong-Hoon Lim","doi":"10.1186/s12882-025-03973-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hypokalemia can result from various causes, with diarrhea being one of the most common. Although rare, chronic hypokalemia can lead to severe acute kidney injury (AKI) that requires dialysis. Therefore, this case study aims to investigate a patient with rectal cancer who, after concurrent chemoradiotherapy and ileostomy, developed chronic hypokalemia owing to prolonged diarrhea, leading to severe AKI with anuria.</p><p><strong>Case presentation: </strong>A 64-year-old man with a history of rectal cancer, ileostomy, and hypertension was admitted for severe AKI with anuria. He had developed severe hypokalemia due to chronic diarrhea. Despite having no prior kidney disease, his serum creatinine increased to 4.8 mg/dL, and potassium dropped to 2.2 mmol/L. Initial treatment included hemodialysis for anuric AKI with metabolic acidosis. A kidney biopsy revealed renal tubular vacuolization and With-no-lysine kinase (WNK) bodies in the distal tubules, which are characteristic of hypokalemic nephropathy. Potassium replacement therapy led to a gradual recovery of potassium levels and kidney function.</p><p><strong>Conclusion: </strong>This case highlights the importance of timely diagnosis and management of hypokalemic nephropathy through kidney biopsy.</p>","PeriodicalId":9089,"journal":{"name":"BMC Nephrology","volume":"26 1","pages":"149"},"PeriodicalIF":2.2000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934709/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Nephrology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12882-025-03973-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Hypokalemia can result from various causes, with diarrhea being one of the most common. Although rare, chronic hypokalemia can lead to severe acute kidney injury (AKI) that requires dialysis. Therefore, this case study aims to investigate a patient with rectal cancer who, after concurrent chemoradiotherapy and ileostomy, developed chronic hypokalemia owing to prolonged diarrhea, leading to severe AKI with anuria.

Case presentation: A 64-year-old man with a history of rectal cancer, ileostomy, and hypertension was admitted for severe AKI with anuria. He had developed severe hypokalemia due to chronic diarrhea. Despite having no prior kidney disease, his serum creatinine increased to 4.8 mg/dL, and potassium dropped to 2.2 mmol/L. Initial treatment included hemodialysis for anuric AKI with metabolic acidosis. A kidney biopsy revealed renal tubular vacuolization and With-no-lysine kinase (WNK) bodies in the distal tubules, which are characteristic of hypokalemic nephropathy. Potassium replacement therapy led to a gradual recovery of potassium levels and kidney function.

Conclusion: This case highlights the importance of timely diagnosis and management of hypokalemic nephropathy through kidney biopsy.

需要血液透析的低钾血症引起的严重急性肾损伤伴无尿:一个案例研究。
背景:低钾血症可由多种原因引起,腹泻是最常见的原因之一。虽然罕见,慢性低钾血症可导致严重的急性肾损伤(AKI),需要透析。因此,本病例研究旨在调查一例直肠癌患者,该患者在同步放化疗和回肠造口术后,由于长期腹泻而发生慢性低钾血症,导致严重AKI并无尿。病例介绍:一名64岁男性,有直肠癌、回肠造口术和高血压病史,因严重AKI合并无尿而入院。由于慢性腹泻,他患上了严重的低钾血症。尽管之前没有肾脏疾病,他的血清肌酐升高到4.8 mg/dL,钾下降到2.2 mmol/L。无尿AKI合并代谢性酸中毒的初始治疗包括血液透析。肾活检显示肾小管空泡和远端小管有无赖氨酸激酶(WNK)小体,这是低钾血症肾病的特征。钾替代疗法导致钾水平和肾功能的逐渐恢复。结论:本病例强调了通过肾活检及时诊断和处理低钾血症肾病的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信