The importance of standardisation and challenges of dosimetry in conventional preclinical radiation biology research.

IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Mark A Hill, Ileana Silvestre Patallo, Adam H Aitkenhead, Magdalena Bazalova-Carter, Rebecca Carter, Simeon Nill, Andrew Nisbet, Mihaela Ghita-Pettigrew, Yannick Poirier, Kevin M Prise, Anna Subiel, Giuseppe Schettino
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引用次数: 0

Abstract

To fully exploit the prospects presented by the increasing focus on biological approaches for enhancing radiotherapy outcomes, improvements in repeatability and translatability of radiobiological and preclinical studies are required. This requires the development and adoption of appropriate dosimetric standards and reproducible approaches to increase confidence in the studies, enabling inter-laboratory validation and facilitating clinical translation. An IPEM Working-Party reviewed the current status and challenges associated with dosimetry of medium-energy X-rays and make recommendations with the aim to optimize the potential clinical significance of radiobiological preclinical investigations. The paper discusses the currently available resources with technical recommendations for performing dosimetry in medium-energy X-rays, along with the consequences of lack of standardization and implications of dose inhomogeneity. It is clear that there is still a gap in understanding the needs for standardisation of dosimetric aspects of preclinical and radiobiological studies. It is recommended that these radiobiology studies should be conducted in partnership with medical/radiation physicists. This collaboration ensures the correct utilization of suitable dosimetry systems, thus guaranteeing accuracy and consistency of dose delivery. Appropriate calibration and traceability to national/international standards laboratory, along with regular quality assurance of radiation devices are paramount to reproducibility. Additionally, it is critical that experimental details and associated dosimetry are sufficiently reported to ensure accurate replication that enables reanalysis including evaluation of dose distributions. Increasing awareness among the researchers and the funding bodies was identified as a crucial step to improve translatability and appropriate resources are budgeted to increase the value for money of research proposals. Advances in knowledge: The proposed recommendations will serve as a vital resource for researchers, encouraging uniformity in experimental design and improving the translatability of preclinical research to clinical settings.

剂量学标准化在常规临床前放射生物学研究中的重要性和挑战。
为了充分利用日益关注生物方法以提高放射治疗结果所呈现的前景,需要改进放射生物学和临床前研究的可重复性和可翻译性。这需要制定和采用适当的剂量学标准和可重复的方法,以增加对研究的信心,使实验室间验证和促进临床转化。IPEM工作组审查了中能量x射线剂量学的现状和挑战,并提出建议,旨在优化放射生物学临床前研究的潜在临床意义。本文讨论了在中能量x射线中进行剂量测定的现有资源和技术建议,以及缺乏标准化的后果和剂量不均匀的影响。很明显,在理解临床前和放射生物学研究的剂量学方面的标准化需求方面仍然存在差距。建议这些放射生物学研究应与医学/放射物理学家合作进行。这种合作确保了适当剂量测定系统的正确使用,从而保证了剂量传递的准确性和一致性。适当的校准和国家/国际标准实验室的可追溯性,以及定期的辐射设备质量保证对再现性至关重要。此外,至关重要的是,实验细节和相关剂量学的充分报告,以确保准确的复制,从而能够进行再分析,包括剂量分布的评估。提高研究人员和供资机构的认识被认为是改善可转译性的关键步骤,并为提高研究建议的资金价值编列了适当的预算资源。知识的进步:提出的建议将成为研究人员的重要资源,鼓励实验设计的一致性,并提高临床前研究到临床环境的可翻译性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
British Journal of Radiology
British Journal of Radiology 医学-核医学
CiteScore
5.30
自引率
3.80%
发文量
330
审稿时长
2-4 weeks
期刊介绍: BJR is the international research journal of the British Institute of Radiology and is the oldest scientific journal in the field of radiology and related sciences. Dating back to 1896, BJR’s history is radiology’s history, and the journal has featured some landmark papers such as the first description of Computed Tomography "Computerized transverse axial tomography" by Godfrey Hounsfield in 1973. A valuable historical resource, the complete BJR archive has been digitized from 1896. Quick Facts: - 2015 Impact Factor – 1.840 - Receipt to first decision – average of 6 weeks - Acceptance to online publication – average of 3 weeks - ISSN: 0007-1285 - eISSN: 1748-880X Open Access option
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