Advances in green sample preparation methods for bioanalytical laboratories focusing on drug analysis.

IF 1.9 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Bioanalysis Pub Date : 2025-03-24 DOI:10.1080/17576180.2025.2481026

Rajeev Jain, Bharti Jain, Lateefa A Al-Khateeb, Sarah Alharthi, Mohammad M Ghoneim, Mohamed AbdElrahman, Abdullah S Alanazi

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引用次数: 0

Abstract

Bioanalytical laboratories face significant challenges in sample preparation due to the complexity of biological matrices and the low concentrations of target analytes. This review focuses on advances in green sample preparation (GSP) techniques tailored to meet these challenges while promoting sustainability. Innovations in sorbents, including metal-organic frameworks (MOFs), magnetic nanoparticles (MNPs), sol-gel-based materials, molecularly imprinted polymers (MIPs), carbon-based materials, and natural sorbents like cellulose and kapok fiber, have enhanced extraction efficiency and selectivity. Green solvents such as deep eutectic solvents (DES), ionic liquids (ILs), supramolecular solvents (SUPRAs), and switchable hydrophilicity solvents (SHSs) further reduce environmental impact by minimizing toxic solvent use. This review highlights their use in drug analysis, emphasizing their roles in enhancing extraction efficiency, selectivity, and environmental sustainability. Recent applications demonstrate the integration of these sorbents and solvents into bioanalytical workflows, significantly improving analytical performance while adhering to Green Analytical Chemistry (GAC) principles. It is anticipated that this comprehensive review will aid scholars in the formulation of selective, rapid, environmentally friendly, straightforward, sensitive, and precise analytical methodologies for bioanalysis, thereby promoting innovation and sustainability within drug analysis protocols.

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以药物分析为重点的生物分析实验室绿色样品制备方法的进展。

由于生物基质的复杂性和目标分析物的低浓度，生物分析实验室在样品制备方面面临着重大挑战。这篇综述的重点是绿色样品制备（GSP）技术的进展，以满足这些挑战，同时促进可持续性。吸附剂的创新，包括金属有机框架（MOFs）、磁性纳米颗粒（MNPs）、溶胶-凝胶基材料、分子印迹聚合物（MIPs）、碳基材料以及纤维素和木棉纤维等天然吸附剂，都提高了提取效率和选择性。绿色溶剂，如深共晶溶剂（DES）、离子液体（ILs）、超分子溶剂（SUPRAs）和可切换亲水性溶剂（SHSs），通过最大限度地减少有毒溶剂的使用，进一步减少了对环境的影响。本文综述了它们在药物分析中的应用，强调了它们在提高提取效率、选择性和环境可持续性方面的作用。最近的应用表明，将这些吸附剂和溶剂集成到生物分析工作流程中，在坚持绿色分析化学（GAC）原则的同时，显著提高了分析性能。预计这一综合综述将有助于学者们制定选择性、快速、环保、直接、敏感和精确的生物分析分析方法，从而促进药物分析方案的创新和可持续性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioanalysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

3.30

自引率

16.70%

发文量

审稿时长

2 months

期刊介绍： Reliable data obtained from selective, sensitive and reproducible analysis of xenobiotics and biotics in biological samples is a fundamental and crucial part of every successful drug development program. The same principles can also apply to many other areas of research such as forensic science, toxicology and sports doping testing. The bioanalytical field incorporates sophisticated techniques linking sample preparation and advanced separations with MS and NMR detection systems, automation and robotics. Standards set by regulatory bodies regarding method development and validation increasingly define the boundaries between speed and quality. Bioanalysis is a progressive discipline for which the future holds many exciting opportunities to further reduce sample volumes, analysis cost and environmental impact, as well as to improve sensitivity, specificity, accuracy, efficiency, assay throughput, data quality, data handling and processing. The journal Bioanalysis focuses on the techniques and methods used for the detection or quantitative study of analytes in human or animal biological samples. Bioanalysis encourages the submission of articles describing forward-looking applications, including biosensors, microfluidics, miniaturized analytical devices, and new hyphenated and multi-dimensional techniques. Bioanalysis delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for the modern bioanalyst.