Packed red blood cell transfusion: a catalyst for thrombosis in patients with traumatic brain injury?

IF 1.5 4区医学 Q4 NEUROSCIENCES

Brain injury Pub Date : 2025-03-24 DOI:10.1080/02699052.2025.2481613

Lily Nguyen, Jeffry Nahmias, Patrick Chen, Jefferson Chen, Michael Lekawa, Jordan Shin, Areg Grigorian

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引用次数: 0

Abstract

Introduction: This study investigated the relationship between trauma patients with TBI who did and did not receive blood product transfusions and the incidence of venous thromboembolism (VTE) hypothesizing transfusions increase VTE risk.

Methods: The Trauma Quality Improvement Program (TQIP) was queried from 2017 to 2021 to identify adult (≥18 years-old) patients with TBI. Patients with TBI receiving any blood product transfusions within 4 h of arrival were compared to those who did not. Outcomes were compared using bivariate analyses and a multivariable logistic regression to identify predictors of VTE.

Results: Of 451,061 patients with TBI, 32,276 (7.2%) patients received a blood transfusion. Thrombotic events were more frequently observed in transfused patients such as VTE (7.6% vs 1.4%, p < 0.001), comprised of deep vein thrombosis (6.0% vs 1.1%, p < 0.001) and pulmonary embolism (2.3% vs 0.4%, p < 0.001). Blood product transfusion was associated with an increased risk of VTE (OR 1.34, CI 1.11-1.62, p = 0.003). However, when individually analyzed, only pRBC transfusion was independently associated with increased VTE risk (OR 1.37, CI 1.24-1.51, p < 0.001).

Conclusions: Trauma patients with TBI undergoing early blood product transfusion had a nearly 50% increased risk of VTE, compared to patients not undergoing transfusion. This risk was primarily attributed to the use of pRBC.

Level of evidence: IV (therapeutic).

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来源期刊

Brain injury 医学-康复医学

CiteScore

3.50

自引率

5.30%

发文量

148

审稿时长

12 months

期刊介绍： Brain Injury publishes critical information relating to research and clinical practice, adult and pediatric populations. The journal covers a full range of relevant topics relating to clinical, translational, and basic science research. Manuscripts address emergency and acute medical care, acute and post-acute rehabilitation, family and vocational issues, and long-term supports. Coverage includes assessment and interventions for functional, communication, neurological and psychological disorders.