Association between triglyceride-glucose index and its combination with obesity indicators and depression: findings from NHANES 2005-2020.

IF 3.2 3区医学 Q2 PSYCHIATRY

Frontiers in Psychiatry Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI:10.3389/fpsyt.2025.1533819

Hongli Sun, Wei He, Jingyu Bu, Huifang Zhang, Huimei Huang, Kai Ma

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Abstract

Background: The relationship between the triglyceride-glucose (TyG) index, its combination with obesity indicators, and depression remains understudied in the American population.

Methods: This cross-sectional study analyzed data from 10,423 adults in the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2020. We employed multivariable logistic regression analysis, smoothing techniques, generalized additive models, stratified analyses, and sensitivity analyses to examine the relationship between TyG, its combination (TyG-WC, TyG-WHtR, TyG-BMI) with obesity indicators, and depression.

Results: The results indicate that the TyG index, TyG-WC, TyG-WHtR, TyG-BMI, and depression exhibited a significant statistical association with depressive symptoms (all P for trend < 0.001). Specifically, a one-unit increase in the TyG index correlated with a 37% increase in the risk of depressive symptoms (95% CI: 1.21-1.55), a one-unit increase in TyG-WC correlated with a 3.26 times increase in the risk of depressive symptoms (95% CI: 2.22-4.80), a one-unit increase in TyG-WHtR correlated with a 27% increase in the risk of depressive symptoms (95% CI: 1.18-1.36), and a one-unit increase in TyG-BMI correlated with a 2.30 times increase in the risk of depressive symptoms (95% CI: 1.72-3.08). There was a significant nonlinear correlation between TyG-WC, TyG-WHtR, and TyG-BMI with depressive symptoms (all P for nonlinearity < 0.001), except for a linear correlation between the TyG index and depressive symptoms (P for linearity < 0.001).

Conclusion: Monitoring the TyG index, TyG-WC, TyG-WHtR, TyG-BMI may facilitate depression risk assessment and prevention.

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来源期刊

Frontiers in Psychiatry Medicine-Psychiatry and Mental Health

CiteScore

6.20

自引率

8.50%

发文量

2813

审稿时长

14 weeks

期刊介绍： Frontiers in Psychiatry publishes rigorously peer-reviewed research across a wide spectrum of translational, basic and clinical research. Field Chief Editor Stefan Borgwardt at the University of Basel is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. The journal''s mission is to use translational approaches to improve therapeutic options for mental illness and consequently to improve patient treatment outcomes.