Mind-Body Intervention in Chronic Lymphocytic Leukemia during the Watch-and-Wait Phase: Benefits Linked to Intervention Duration.

IF 1.1 4区医学 Q3 HEMATOLOGY

Acta Haematologica Pub Date : 2025-03-24 DOI:10.1159/000545407

Shirley Shapira, Barak Mizrahi, Naama Hirschberger, Noa Rabinowicz, Adi Zoref-Lorenz, Natalie Flaks-Manov

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引用次数: 0

Abstract

Introduction: Mind-body interventions (MBIs) are therapeutic practices that target the interactions between cognitive, emotional, and physiological systems to influence health outcomes. Previously, we demonstrated that MBI prolonged lymphocyte doubling time and treatment-free survival (TFS) in treatment-naïve chronic lymphocytic leukemia (CLL) patients during the watch-and-wait phase. In this follow-up study, we investigated the long-term effects of MBI on TFS after the intervention ceased.

Methods: Sixty participants from the initial study (34 who received intervention vs. 26 controls) were followed for an additional period of 20 months. TFS was assessed from the end of the intervention to the initiation of CLL therapy or death, using Kaplan-Meier analysis and the log-rank test.

Results: By the end of the follow-up, 9 participants who previously received MBI and 6 controls initiated CLL treatment. No significant difference in TFS was found between the groups (log-rank test, p = 0.65).

Conclusion: While MBI provided a clear advantage as long as it continued, our follow-up analysis suggests this effect diminishes after the intervention ends. Continuous or repeated MBI may be necessary for sustained improvements in TFS.

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慢性淋巴细胞白血病在观察和等待阶段的身心干预：与干预时间有关的益处。

身心干预（MBI）是针对认知、情感和生理系统之间的相互作用来影响健康结果的治疗实践。先前，我们证明MBI延长了treatment-naïve慢性淋巴细胞白血病（CLL）患者在观察和等待阶段的淋巴细胞倍增时间（LDT）和无治疗生存期（TFS）。在这项随访研究中，我们调查了干预停止后MBI对TFS的长期影响。方法：来自最初研究的60名参与者（34名接受干预，26名对照组）被随访了20个月。使用Kaplan-Meier分析和log-rank检验评估从干预结束到CLL治疗开始或死亡的TFS。结果：在随访结束时，先前接受MBI的9名参与者和6名对照组开始了CLL治疗。两组间TFS差异无统计学意义（log-rank检验p = 0.65）。结论：虽然只要MBI持续，它就有明显的优势，但我们的随访分析表明，这种效果在干预结束后会减弱。持续或重复的MBI可能是持续改善TFS的必要条件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Haematologica 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Acta Haematologica'' is a well-established and internationally recognized clinically-oriented journal featuring balanced, wide-ranging coverage of current hematology research. A wealth of information on such problems as anemia, leukemia, lymphoma, multiple myeloma, hereditary disorders, blood coagulation, growth factors, hematopoiesis and differentiation is contained in first-rate basic and clinical papers some of which are accompanied by editorial comments by eminent experts. These are supplemented by short state-of-the-art communications, reviews and correspondence as well as occasional special issues devoted to ‘hot topics’ in hematology. These will keep the practicing hematologist well informed of the new developments in the field.