The correlation analysis between Normalized Wall Index and cerebral perfusion in patients with Mild Carotid Artery Stenosis under 3.0T MRI.

IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yonggang Cai, Shouming Chen, Tongyu Shang, Binze Han, Lei Zhang, Changyan Xu, Zhibin He, Ting Yin
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Abstract

Background: To explore the relationship between Normalized Wall Index (NWI) and Magnetic Resonance Perfusion Imaging Parameters in Patients with Mild Carotid Artery Stenosis.

Methods: Initially, an analysis was conducted on 40 patients from our institution, and we identified through ultrasonographic examinations conducted between July 2021 and August 2022. These patients exhibited carotid artery plaques with mild luminal narrowing (with stenosis rates ranging from 20 to 50%, following the criteria of the North American Symptomatic Carotid Endarterectomy Trial, NASCET). All cases underwent high-resolution magnetic resonance imaging (MRI) of the carotid arteries and cerebral perfusion assessments using 3.0T MRI during the specified timeframe. Based on whether the cerebral hemisphere in the carotid artery supply region had experienced ischemic events, including Transient Ischemic Attacks (TIAs), patients were categorized into symptomatic and asymptomatic groups. Subsequently, the Normalized Wall Index (NWI) of the carotid arteries and the area of abnormal perfusion on the same side of the brain were calculated for each group.

Results: In the symptomatic group, all patients exhibited perfusion abnormalities in the internal carotid artery supply region, whereas only some patients in the asymptomatic group showed such abnormalities. The NWI of plaques in the symptomatic group was significantly higher than that in the asymptomatic group (P < 0.05).

Conclusion: The range of prolongation in mean transit time (MTT) and time to peak (TTP) in patients with perfusion abnormalities was positively correlated with NWI and stenosis rates. The association with NWI was more pronounced and statistically significant (P < 0.05).

3.0T MRI下颈动脉轻度狭窄患者归一化壁指数与脑灌注的相关性分析
背景:探讨颈动脉轻度狭窄患者归一化壁指数(NWI)与磁共振灌注成像参数的关系。方法:首先,我们对我院40例患者进行了分析,并通过2021年7月至2022年8月进行的超声检查确定。这些患者表现为颈动脉斑块伴轻度管腔狭窄(根据北美症状性颈动脉内膜切除术试验(NASCET)的标准,狭窄率从20%到50%不等)。所有病例均在规定时间内行颈动脉高分辨率磁共振成像(MRI)和3.0T MRI脑灌注评估。根据颈动脉供血区大脑半球是否发生过缺血事件,包括短暂性脑缺血发作(tia),将患者分为有症状组和无症状组。计算各组颈动脉归一化壁指数(Normalized Wall Index, NWI)及脑同侧异常灌注面积。结果:有症状组所有患者均出现颈内动脉供应区灌注异常,无症状组仅有部分患者出现灌注异常。有症状组斑块NWI明显高于无症状组(P)。结论:灌注异常患者平均转运时间(MTT)和到达峰值时间(TTP)的延长范围与NWI和狭窄率呈正相关。与NWI的关联更为明显且具有统计学意义(P
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来源期刊
BMC Medical Imaging
BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
4.60
自引率
3.70%
发文量
198
审稿时长
27 weeks
期刊介绍: BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.
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