Sprayed hyaluronic acid based multidrug composite hydrogel for postoperative colorectal cancer ultra-efficient long-lasting multi-stage immuno-chemo synergistic therapy.

IF 12.2 2区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Ya Wang, Xiaojiang Zhang, Yujie Zhang, Feiyu Shi, Siyuan Du, Zhe Zhang, Chenyu Zhao, Siyuan Luo, Pengqian Wang, Daocheng Wu, Junjun She
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引用次数: 0

Abstract

To enhance the therapeutic efficacy of postoperative colorectal cancer treatment and prevent peritoneal metastasis, we propose a strategy utilizing the photothermal-induced ultra-efficient and long-lasting multi-stage immuno-chemo synergistic therapy. To implement this strategy, oxaliplatin (OXA), curcumin (Cur), and Mn2+ were coordinated to form infinite coordination polymer nanoparticles (OXA-Mn(II)-Cur ICP NPs). These nanoparticles are encapsulated with polydopamine (PDA) to create OXA-Mn(II)-Cur ICP@PDA NPs, which are subsequently embedded in a sprayable hyaluronic acid-based hydrogel. The resulting ICP@PDA NPs@composite hydrogel exhibits strong tissue adhesion and segmented pH-responsive drug release properties. Notably, the hydrogel can sustainably release drugs for over 20 days in vivo, maximizing local drug concentration while minimizing systemic toxic side effects. Each component of the composite hydrogel serves multiple functions, and its application to postoperative tumor sites enables long-term, dual-pathway, multi-stage immune activation. This immune response synergizes with chemotherapy to achieve a highly effective therapeutic outcome. In vivo experiments demonstrated that the composite hydrogel effectively eliminates residual tumors, ensuring a 100% survival rate without recurrence for 80 days in treated mice. Furthermore, it inhibits peritoneal metastasis and completely eradicates intraperitoneal tumors within 20 days. The ICP@PDA NPs@composite hydrogel represents a promising therapeutic platform for postoperative colorectal cancer treatment and metastasis prevention.

喷雾透明质酸多药复合水凝胶用于结直肠癌术后超高效长效多期免疫化疗协同治疗。
为了提高结直肠癌术后治疗的疗效,预防腹膜转移,我们提出了一种利用光热诱导的超高效、长效多期免疫化疗协同治疗的策略。为了实现这一策略,奥沙利铂(OXA)、姜黄素(Cur)和Mn2+被配位形成无限配位聚合物纳米颗粒(OXA- mn (II)-Cur ICP NPs)。这些纳米颗粒被聚多巴胺(PDA)包裹,形成OXA-Mn(II)-Cur ICP@PDA NPs,随后嵌入可喷雾的透明质酸基水凝胶中。所得的ICP@PDA NPs@composite水凝胶具有很强的组织粘附性和分段ph响应药物释放特性。值得注意的是,水凝胶可以在体内持续释放药物超过20天,最大限度地提高局部药物浓度,同时最大限度地减少全身毒副作用。复合水凝胶的每种成分都具有多种功能,将其应用于术后肿瘤部位可以实现长期、双途径、多阶段的免疫激活。这种免疫反应与化疗协同作用,达到非常有效的治疗效果。体内实验表明,复合水凝胶有效地消除残留肿瘤,确保治疗小鼠80天内100%存活率无复发。此外,它还能抑制腹膜转移,并在20天内完全根除腹膜内肿瘤。ICP@PDA NPs@composite水凝胶为结直肠癌术后治疗和转移预防提供了一个很有前景的治疗平台。
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来源期刊
Materials Horizons
Materials Horizons CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
18.90
自引率
2.30%
发文量
306
审稿时长
1.3 months
期刊介绍: Materials Horizons is a leading journal in materials science that focuses on publishing exceptionally high-quality and innovative research. The journal prioritizes original research that introduces new concepts or ways of thinking, rather than solely reporting technological advancements. However, groundbreaking articles featuring record-breaking material performance may also be published. To be considered for publication, the work must be of significant interest to our community-spanning readership. Starting from 2021, all articles published in Materials Horizons will be indexed in MEDLINE©. The journal publishes various types of articles, including Communications, Reviews, Opinion pieces, Focus articles, and Comments. It serves as a core journal for researchers from academia, government, and industry across all areas of materials research. Materials Horizons is a Transformative Journal and compliant with Plan S. It has an impact factor of 13.3 and is indexed in MEDLINE.
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