Differences Between Patients With Multiple System Atrophy With Predominant Parkinsonism and Parkinson's Disease Based on fNIRS and Gait Analysis

Abstract

Objective

To investigate the differences in gait parameters and cortical activity during a single-task walking (STW) and cognitive dual-task walking (DTW) between multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson's disease (PD).

Methods

24 MSA-P patients, 20 PD patients, and 22 healthy controls (HCs) were enrolled. Gait parameters were collected using a portable inertial measurement unit system, and the relative change of oxyhemoglobin (ΔHbO₂) in the bilateral frontal and sensorimotor cortex was obtained by functional near-infrared spectroscopy during walking with and without cognitive tasks.

Results

MSA-P patients had increased step length variability and higher ΔHbO₂ in the right dorsolateral prefrontal cortex (DLPFC), relative to PD patients and HCs during the DTW condition. Meanwhile, MSA-P patients exhibited higher step length variability and ΔHbO₂ in the right DLPFC during DTW compared to STW. Furthermore, mild negative correlations were found between the ΔHbO₂ in the right DLPFC and step length, while there was a mild positive correlation between ΔHbO₂ and step length variability during the DTW condition. Notably, receiver operating characteristic (ROC) curve analysis uncovered that the areas under the curve (AUCs) of the ΔHbO₂ of the right DLPFC and step length variability during DTW were 0.798 (95% confidence interval [CI]: 0.651–0.945, sensitivity = 0.650, specificity = 0.958) and 0.721 (95% CI: 0.570–0.871, sensitivity = 0.625, specificity = 0.800), respectively.

Conclusion

MSA-P patients demonstrate more severe gait disturbance and increased DLPFC activity compared with PD patients and HCs. Gait parameters and cortical activity could be a potential features discerning MSA-P patients and PD patients.