Spectroscopic studies of molecules in sol-gel silica monoliths and thin films

IF 2.3 4区 材料科学 Q2 MATERIALS SCIENCE, CERAMICS
Jeffrey I. Zink
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引用次数: 0

Abstract

This article about sol-gel research in North America is focused on transparent sol-gel silica monoliths and nano-structured thin films containing encapsulated molecules. The research was a collaborative effort carried out at the University of California Los Angeles (UCLA). Our research was focused on two goals: using optical spectroscopy to understand the chemical and physical changes occurring during the sol to the xerogel transformation; and using spectroscopy to understand what was happening to the molecules themselves after encapsulation. The first section is a brief discussion of molecular probes used to monitor in real time the hydrolysis, condensation, gelation and drying of tetraethoxysilane (TEOS) formed in optical cuvettes. In the second section, we introduce dip coating of one hundred nanometer thin films and methods for measuring thickness and chemical changes in real time during film pulling. We include surfactant templated mesostructured films and real time observation of the structure development. Third, we design molecules to add to the initial sol such that they are placed in specific regions of the ordered structure of the templated film. We describe spectroscopic methods that prove their placement and use pairs of molecules for physical studies including intermolecular energy transfer. Finally, we describe “gentle” synthesis methods for encapsulating enzymes and other proteins that retain their optical and enzymatic properties. Spectroscopy provided quantitative information about the sol-gel processes, enzymatic activity, and optical sensor applications.

Graphical Abstract

The Graphical Abstract depicts an octagonal array of sol-gel silica monoliths containing enzymes. The largest monoliths have dimensions of approximately 5 × 5 × 15 mm. The original sol was placed in an optical cuvette and hydrolysis, condensation and slow, controlled drying in the cuvette produced the parallelepiped cuboid-shaped monoliths without cracking. The colors are caused by encapsulated metalloenzymes and the absorption spectra are the same as those of the enzymes in solution. In the center of the array is an artist’s depiction of an enzyme surrounded by the amorphous silica glass.

溶胶-凝胶硅胶整体体和薄膜分子的光谱研究
这篇关于溶胶-凝胶研究在北美的重点是透明溶胶-凝胶硅胶整体和纳米结构薄膜包含封装分子。这项研究是加州大学洛杉矶分校(UCLA)的一项合作研究。我们的研究主要集中在两个目标上:利用光谱学来了解溶胶到干凝胶转化过程中发生的化学和物理变化;并利用光谱学来了解包裹后分子本身发生了什么。第一部分简要讨论了用于实时监测在光学试管中形成的四乙氧基硅烷(TEOS)的水解、缩合、凝胶化和干燥的分子探针。在第二部分,我们介绍了一百纳米薄膜的浸涂,以及在拉膜过程中实时测量厚度和化学变化的方法。我们包括表面活性剂模板化的介结构薄膜和结构发展的实时观察。第三,我们设计分子添加到初始溶胶中,使它们被放置在模板膜的有序结构的特定区域。我们描述了光谱方法,证明他们的位置和使用对分子的物理研究,包括分子间的能量转移。最后,我们描述了“温和”的合成方法,用于封装酶和其他保留其光学和酶性质的蛋白质。光谱学提供了关于溶胶-凝胶过程、酶活性和光学传感器应用的定量信息。图形摘要描述了一个含有酶的溶胶-凝胶硅胶单体的八角形阵列。最大的单体石尺寸约为5 × 5 × 15毫米。将原始溶胶置于光学比色皿中,在比色皿中水解、冷凝和缓慢、可控的干燥产生了不开裂的平行六面体长方体形状的单体。这些颜色是由被包裹的金属酶引起的,其吸收光谱与溶液中的金属酶相同。在阵列的中心是一个艺术家描绘的酶被无定形的硅玻璃包围。
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来源期刊
Journal of Sol-Gel Science and Technology
Journal of Sol-Gel Science and Technology 工程技术-材料科学:硅酸盐
CiteScore
4.70
自引率
4.00%
发文量
280
审稿时长
2.1 months
期刊介绍: The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.
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