A review on the lncRNA-miRNA-mRNA regulatory networks involved in inflammatory processes in Alzheimer’s disease

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-03-23 DOI:10.1016/j.brainres.2025.149595

Masoumeh Kazemi , Mahla Sanati , Mahmoud Shekari Khaniani , Soudeh Ghafouri-Fard

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Abstract

Alzheimer’s disease is a progressive neurodegenerative condition that is the most frequent reason for dementia. Due to the increasing trend of aging in societies, it will place a large social and financial burden on society. Although beta amyloid plaques and the formation of neurofibrillary tangles are mentioned as the main events in this disorder, the exact molecular pathology and inflammatory regulatory networks involved in neuroinflammatory events, as a fundamental pathogenic mechanism remain unknown. Understanding these molecular network pathways in addition to helping to understand the pathogenesis of Alzheimer’s disease, can also help in the early diagnosis as well as the control of inflammatory processes that are involved in its progression. So, in this study, we intend to have an overview on the regulatory lncRNAs of Alzheimer’s disease and their related miRNA and mRNAs, as well as the relationship of these regulatory pathways with inflammatory processes, so that we can provide a perspective for future studies in the field of diagnosis and possibly treatment of this disorder.

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阿尔茨海默病炎症过程中lncRNA-miRNA-mRNA调控网络的研究进展

阿尔茨海默病是一种进行性神经退行性疾病，是痴呆症最常见的原因。由于社会老龄化趋势的加剧，它将给社会带来巨大的社会和经济负担。虽然β -淀粉样蛋白斑块和神经原纤维缠结的形成被认为是这种疾病的主要事件，但神经炎症事件的确切分子病理和炎症调节网络作为一种基本的致病机制尚不清楚。了解这些分子网络通路除了有助于了解阿尔茨海默病的发病机制外，还有助于早期诊断以及控制其进展中涉及的炎症过程。因此，在本研究中，我们打算对阿尔茨海默病的调控lncrna及其相关的miRNA和mrna，以及这些调控通路与炎症过程的关系进行综述，为今后在阿尔茨海默病的诊断和可能的治疗领域的研究提供一个视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.