TiO2-Ag nanostructured photocatalyst for viral inactivation: A preliminary study using protein models

IF 5.2 2区化学 Q1 CHEMISTRY, APPLIED

Catalysis Today Pub Date : 2025-03-17 DOI:10.1016/j.cattod.2025.115278

Elisabetta Roberto , Ilaria De Pasquale , Massimo Dell’Edera , Nicoletta Depalo , Elisabetta Fanizza , Roberto Comparelli , Maria Lucia Curri

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引用次数: 0

Abstract

The rapid emergence of viral infections, such as SARS-CoV-2, underscores the urgent need for innovative antiviral strategies. This study explores the photocatalytic effectiveness of synthesized mesoporous mTiO₂-Ag nanostructures in denaturing viral proteins, thereby inhibiting viral spread. Utilizing protein models, specifically bovine serum albumin (BSA) and the spike protein subunit S1 (S1SP) of SARS-CoV-2, we evaluated the nanocomposite's ability to degrade high molecular weight proteins, simulating the interactions between photocatalysts and viral proteins. Our findings indicate that the mTiO₂-Ag nanocomposite exhibits enhanced photocatalytic performance, effectively disrupting viral structures through reactive oxygen species (ROS) generation and physical interactions. This approach not only provides insights into the mechanisms of viral inactivation, pointing out the effect of photocatalytically generated ROS, as ^•OH, but also offers a safe alternative for assessing the antiviral properties of nanomaterials without the need for handling pathogenic viruses. The results support the potential application of photocatalytic nanomaterials in disinfection strategies, promoting safer and more effective solutions for controlling viral infections in various environments.

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来源期刊

Catalysis Today 化学-工程：化工

CiteScore

11.50

自引率

3.80%

发文量

573

审稿时长

2.9 months

期刊介绍： Catalysis Today focuses on the rapid publication of original invited papers devoted to currently important topics in catalysis and related subjects. The journal only publishes special issues (Proposing a Catalysis Today Special Issue), each of which is supervised by Guest Editors who recruit individual papers and oversee the peer review process. Catalysis Today offers researchers in the field of catalysis in-depth overviews of topical issues. Both fundamental and applied aspects of catalysis are covered. Subjects such as catalysis of immobilized organometallic and biocatalytic systems are welcome. Subjects related to catalysis such as experimental techniques, adsorption, process technology, synthesis, in situ characterization, computational, theoretical modeling, imaging and others are included if there is a clear relationship to catalysis.