Neurobehavioral characteristics and symptomatic correlations of audiovisual multisensory integration in schizophrenia: A systematic review and meta-analysis
Enze Tang , Nuo Chen , Jian Li , Yueyao Liu , Hongwei Ding , Hui Chen
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引用次数: 0
Abstract
Background
Multisensory integration (MSI) avoids cognitive overload, and the traditional all-or-nothing perspective for dysfunctional MSI in schizophrenia has been increasingly challenged. This study aimed to systematically review and meta-analyze extant evidence on audiovisual MSI in schizophrenia.
Methods
We searched Web of Science, PubMed, PsycINFO and PsycARTICLES databases from inception until April 16th, 2024. Studies using appropriate audiovisual integration tasks to compare either behavioral or neural responses between schizophrenia individuals and healthy controls were included. Primary outcome measures included between-group differences (Hedge's g) and symptomatic correlations (Fisher's z) in three components of audiovisual integration tasks, including audiovisual processing, adaptation and integration. The multilevel random-effects models were used to address statistical dependency.
Results
In total, 209 between-group and 116 correlational effect sizes were synthesized from 46 studies, representing 1108 non-overlapped schizophrenia participants and 1084 healthy controls. The overall dysfunctional audiovisual MSI in schizophrenia (g = −0.50, [95 % CI, −0.64 to −0.37]) was primarily ascribed to the impaired audiovisual processing (g = −0.53, [95 % CI, −0.71 to −0.35]) and adaptation (g = −0.71, [95 % CI, −0.99 to −0.42]), rather than integration itself (g = −0.23, [95 % CI, −0.56 to 0.11]). Pooled correlational effect size was extremely small (z = 0.16, [95 % CI, 0.03 to 0.30]).
Conclusions
Individuals with schizophrenia show dysfunctional multisensory processing and adaptation, but preserve a less impaired multisensory integration ability. Our findings provide implications for clinical interventions, as the relatively preserved audiovisual integration ability may serve as a possible avenue for cognitive training programs.
期刊介绍:
Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research:
(1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors;
(2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology;
(3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;