Ultrasmall PtCu nanosheets as a broadband phototheranostic agent in near-infrared biowindow

IF 9.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chinese Chemical Letters Pub Date : 2025-03-12 DOI:10.1016/j.cclet.2025.111059

Ying Zhang , Chuang Shen , Jiaxu Zhang , Qi Shen , Fei Xu , Shengheng Wang , Jiuyi Hu , Faisal Saleem , Feng Huang , Zhimin Luo

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Abstract

Broadband photothermal and photoacoustic agents in the near-infrared (NIR) biowindow are of significance for cancer phototheranostics. In this work, PtCu nanosheets with an average lateral size of less than 10 nm are synthesized as NIR photothermal and photoacoustic agents in vivo, which show strong light absorption from NIR-I to NIR-II biowindows with the photothermal conversion efficiencies of 20.4% under 808 nm laser and 32.7% under 1064 nm laser. PtCu nanosheets functionalized with folic acid-modified thiol-poly(ethylene glycol) (SH-PEG-FA) present good biocompatibility and 4T1 tumor-targeted effect, which give high-contrast photoacoustic imaging and efficient photothermal ablation of 4T1 tumor in both NIR-I and NIR-II biowindows. Our work significantly broadens applications of noble metal-based nanomaterials in the fields of cancer phototheranostics by rationally designing their structures and modulating their physicochemical properties.

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超小PtCu纳米片作为近红外生物窗口的宽带光治疗剂

近红外（NIR）生物窗口中的宽带光热和光声剂在癌症光治疗中具有重要意义。本文在体内合成了平均横向尺寸小于10 nm的PtCu纳米片作为近红外光热和光声剂，其在NIR- i到NIR- ii生物窗口具有较强的光吸收，在808 nm激光下光热转换效率为20.4%，在1064 nm激光下光热转换效率为32.7%。叶酸修饰巯基聚乙二醇（SH-PEG-FA）功能化的PtCu纳米片具有良好的生物相容性和4T1肿瘤靶向效应，可在NIR-I和NIR-II生物窗口中对4T1肿瘤进行高对比度光声成像和高效光热消融。我们的工作通过合理设计贵金属基纳米材料的结构和调节其物理化学性质，大大拓宽了其在癌症光疗领域的应用。

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来源期刊

Chinese Chemical Letters 化学-化学综合

CiteScore

14.10

自引率

15.40%

发文量

8969

审稿时长

1.6 months

期刊介绍： Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.