Rh(III)-Catalyzed Cascade [3+3] Spiroannulation of N-Acyl Ketimines with Iodonium Ylides: Access to Spiro-N,O-Ketals

Abstract

A Rh(III)-catalyzed cascade C-H activation/[3+3]spiroannulation of 3-hydroxy-3-arylisoindolin-1-ones with iodonium ylides has been developed. The method facilitates the efficient and selective construction of spirocyclic compounds in a one-pot manner, offering high yields and excellent conversion. The reaction proceeds via a highly regioselective process, resulting in the formation of spiro-N,O-ketals with remarkable chemo- and stereoselectivity. This strategy provides a valuable protocol for the synthesis of complex spirocyclics with potential applications in medicinal chemistry and materials science.