Exploring Broad-Spectrum Antimicrobial Nanotopographies: Implications for Bactericidal, Antifungal, and Virucidal Surface Design

Abstract

Inspired by the natural defense strategies of insect wings and plant leaves, nanostructured surfaces have emerged as a promising tool in various fields, including engineering, biomedical sciences, and materials science, to combat bacterial contamination and disrupt biofilm formation. However, the development of effective antimicrobial surfaces against fungal and viral pathogens presents distinct challenges, necessitating tailored approaches. Here, we aimed to review the recent advancements of the use of nanostructured surfaces to combat microbial contamination, particularly focusing on their mechano-bactericidal and antifungal properties, as well as their potential in mitigating viral transmission. We comparatively analyzed the diverse geometries and nanoarchitectures of these surfaces and discussed their application in various biomedical contexts, such as dental and orthopedic implants, drug delivery systems, and tissue engineering. Our review highlights the importance of preventing microbial attachment and biofilm formation, especially in the context of rising antimicrobial resistance and the economic impact of biofilms. We also discussed the latest progress in materials science, particularly nanostructured surface engineering, as a promising strategy for reducing viral transmission through surfaces. Overall, our findings underscore the significance of innovative strategies to mitigate microbial attachment and surface-mediated transmission, while also emphasizing the need for further interdisciplinary research in this area to optimize antimicrobial efficacy and address emerging challenges.