Conformational changes in heat- and proton-sensing ion channel in centipedes

IF 10.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2025-03-25 DOI:10.1038/s41594-025-01526-4

引用次数: 0

Abstract

Structural analyses, patch-clamp recordings and molecular dynamic simulations of the heat and proton sensor BRTNaC1 channel in centipedes reveal a ‘twist the wrist’ mechanism induced by proton activation. Heat induces broad conformational changes in BRTNaC1, including rotation and shift in the transmembrane helices to open this channel.

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蜈蚣体内热感应和质子感应离子通道的构象变化

蜈蚣体内热和质子传感器BRTNaC1通道的结构分析、膜片钳记录和分子动力学模拟揭示了质子激活诱导的“扭手腕”机制。热诱导BRTNaC1广泛的构象变化，包括跨膜螺旋的旋转和移位以打开该通道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.