Nebulized hyaluronic acid and xylitol based solution after turbinate radiofrequency ablation. A triple blind randomized multicentric clinical trial.

Acta otorrinolaringologica espanola Pub Date : 2025-03-20 DOI:10.1016/j.otoeng.2025.512218

Christian Calvo-Henríquez, Ainhoa García-Lliberos, Byron Maldonado-Alvarado, Miguel Rodriguez-Iglesias, David Lobo-Duro, Juan Maza-Solano, Serafín Sánchez-Gomez, Isam Alobid

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Abstract

Objective: This prospective, triple blind randomized clinical trial aims to specifically evaluate the effect of Aluneb® (hyaluronic acid plus xilitol) in the postoperative treatment of inferior turbinate radiofrequency in adults compared to nebulized isotonic saline.

Methods: Adults undergoing radiofrequency turbinate ablation were included. Treatment group received Aluneb® (hyaluronic acid plus xylitol) while the control group received nebulized isotonic saline for two months after treatment. Participants were studied the week before surgery (visit 0), and at 7, 15, 30 and 60 days after surgery. At all visits, participants underwent physical examination, rhinomanometry, SNOT-22, and visual analogue scale (VAS) of symptoms.

Results: 34 participants were recruited. Crusts (endoscopy) were less in the Aluneb® hyaluronic acid plus xylitol group. Nasal crusting, epistaxis and nasal obstruction VAS were statistically significant lower. VAS for Rhinorrea, halitosis, cacosmia and pain and nasal resistance obtained lower self-reported values in the hyaluronic acid plus xilitol group, but these differences were not statistically significant.

Conclusions: Hyaluronic acid plus xilitol demonstrated promise in improving postoperative outcomes, future studies with larger sample sizes and different surgical techniques are encouraged.

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鼻甲射频消融后雾化透明质酸和木糖醇溶液。一项三盲随机多中心临床试验。

目的：这项前瞻性、三盲随机临床试验旨在专门评估Aluneb®（透明质酸加西利醇）在成人下鼻甲术后射频治疗中的效果，并与雾化等渗盐水进行比较。方法：接受射频鼻甲消融的成人为研究对象。治疗组给予Aluneb®（透明质酸加木糖醇）治疗，对照组给予等渗生理盐水雾化治疗2个月。参与者在手术前一周（第0次访问）以及手术后7、15、30和60天进行研究。在所有访问中，参与者接受体格检查、鼻测压、SNOT-22和症状视觉模拟量表（VAS）。结果：招募了34名参与者。Aluneb®透明质酸加木糖醇组结痂（内窥镜检查）较少。鼻结皮、鼻出血、鼻塞VAS均有统计学意义。透明质酸加西利醇组鼻臭、口臭、鼻臭、疼痛和鼻阻力VAS自述值较低，但差异无统计学意义。结论：透明质酸加西利醇在改善术后预后方面表现出希望，鼓励未来更大样本量和不同手术技术的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta otorrinolaringologica espanola

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