{"title":"Cardiac neuromodulation with acute intermittent hypoxia in rats with spinal cord injury","authors":"Mehdi Ahmadian, Erin Erskine, Christopher R. West","doi":"10.1113/JP287676","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n \n <div>It is well recognized that the interruption in bulbospinal sympathetic projections is the main cause of cardiovascular instability in individuals and experimental animals with spinal cord injury (SCI). Whether interrupted bulbospinal sympathetic projections contribute to cardiac dysfunction directly (i.e. input to the heart) or indirectly (i.e. vascular influences that alter loading conditions on the heart) post-SCI remains unknown, as does the potential effect of SCI-induced alterations in parasympathetic control on heart function. We employed a sequential pharmacological blockade approach to bridge this knowledge gap and additionally examined whether acute intermittent hypoxia (AIH) is capable of neuromodulating the heart post-SCI. In two experiments, rats were given T3 contusion SCI and survived for 2 weeks. At 2 weeks post-SCI, rats were instrumented with left ventricular and arterial catheters to assess cardiovascular function in response to either a sequential pharmacological blockade targeting different sites of the autonomic neuraxis (experiment 1) or AIH (experiment 2). The findings from experiment 1 revealed that impaired direct sympathetic transmission to the heart underlies the majority of the SCI-induced reduction in heart function post-SCI. The findings from experiment 2 revealed that a single-session of AIH increased left ventricular pressure generation and arterial blood pressure immediately and up to 90 min post-AIH. Together, our findings demonstrate that disrupted bulbospinal sympathetic pathways contribute directly to the SCI-induced impairment in left ventricular function. We also show that a single session of AIH is capable of neuromodulating the heart post-SCI.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </div>\n </section>\n \n <section>\n \n <h3> Key points</h3>\n \n <div>\n <ul>\n \n <li>The loss of sympathetic transmission to the heart is the main cause of reduced cardiac function in a rodent model of spinal cord injury (SCI).</li>\n \n <li>Parasympathetic control remains unaltered post-SCI and does not contribute to reduced cardiac function post-SCI.</li>\n \n <li>Acute intermittent hypoxia neuromodulates the heart and increases left ventricular pressure generating capacity.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":50088,"journal":{"name":"Journal of Physiology-London","volume":"603 7","pages":"2139-2156"},"PeriodicalIF":4.7000,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1113/JP287676","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Physiology-London","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1113/JP287676","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
It is well recognized that the interruption in bulbospinal sympathetic projections is the main cause of cardiovascular instability in individuals and experimental animals with spinal cord injury (SCI). Whether interrupted bulbospinal sympathetic projections contribute to cardiac dysfunction directly (i.e. input to the heart) or indirectly (i.e. vascular influences that alter loading conditions on the heart) post-SCI remains unknown, as does the potential effect of SCI-induced alterations in parasympathetic control on heart function. We employed a sequential pharmacological blockade approach to bridge this knowledge gap and additionally examined whether acute intermittent hypoxia (AIH) is capable of neuromodulating the heart post-SCI. In two experiments, rats were given T3 contusion SCI and survived for 2 weeks. At 2 weeks post-SCI, rats were instrumented with left ventricular and arterial catheters to assess cardiovascular function in response to either a sequential pharmacological blockade targeting different sites of the autonomic neuraxis (experiment 1) or AIH (experiment 2). The findings from experiment 1 revealed that impaired direct sympathetic transmission to the heart underlies the majority of the SCI-induced reduction in heart function post-SCI. The findings from experiment 2 revealed that a single-session of AIH increased left ventricular pressure generation and arterial blood pressure immediately and up to 90 min post-AIH. Together, our findings demonstrate that disrupted bulbospinal sympathetic pathways contribute directly to the SCI-induced impairment in left ventricular function. We also show that a single session of AIH is capable of neuromodulating the heart post-SCI.
Key points
The loss of sympathetic transmission to the heart is the main cause of reduced cardiac function in a rodent model of spinal cord injury (SCI).
Parasympathetic control remains unaltered post-SCI and does not contribute to reduced cardiac function post-SCI.
Acute intermittent hypoxia neuromodulates the heart and increases left ventricular pressure generating capacity.
期刊介绍：
The Journal of Physiology publishes full-length original Research Papers and Techniques for Physiology, which are short papers aimed at disseminating new techniques for physiological research. Articles solicited by the Editorial Board include Perspectives, Symposium Reports and Topical Reviews, which highlight areas of special physiological interest. CrossTalk articles are short editorial-style invited articles framing a debate between experts in the field on controversial topics. Letters to the Editor and Journal Club articles are also published. All categories of papers are subjected to peer reivew.
The Journal of Physiology welcomes submitted research papers in all areas of physiology. Authors should present original work that illustrates new physiological principles or mechanisms. Papers on work at the molecular level, at the level of the cell membrane, single cells, tissues or organs and on systems physiology are all acceptable. Theoretical papers and papers that use computational models to further our understanding of physiological processes will be considered if based on experimentally derived data and if the hypothesis advanced is directly amenable to experimental testing. While emphasis is on human and mammalian physiology, work on lower vertebrate or invertebrate preparations may be suitable if it furthers the understanding of the functioning of other organisms including mammals.
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