Prevalence and Circulating Serotypes of Dengue in Bastar, Chhattisgarh: A Cross-Sectional Study.

IF 2.6 4区 医学 Q3 INFECTIOUS DISEASES
Rani Soni, Dhananjay Tandon, Sahina Hassan, Debashish Samal, Divakar Sharma
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引用次数: 0

Abstract

The dengue virus is a significant re-emerging arbovirus drawing global public health concern. Urbanization, population growth, human mobility, water access, and storage practices contribute to its transmission. This hospital-based cross-sectional study is designed to determine dengue infection and prevalence in the district Bastar, Chhattisgarh. Blood samples were collected from the patients, and based on fever duration, they were tested for nonstructural protein 1 (NS1) antigen and immunoglobulin M (IgM) antibody detection. NS1 positive cases were further tested by RT-PCR for serotyping. Among the 2223 collected samples, 2041 were screened for NS1 and 182 for IgM; among them, the positivity was 55 (2.70%) in NS1 and 23 (12.63%) in IgM, respectively. Overall positivity of the dengue cases was 78 (3.51%); however, sex-wise, male and female, dengue positive cases were 45 and 33, respectively. NS1 was positive in 55 cases (70.51%), and IgM in 23 (29.49%) patients. Among these 78 cases, 4 NS1 and 2 IgM cases have shown symptoms of warning signs, while the rest of the cases have shown nonwarning symptoms. Among the 55 NS1 positive cases, the age group (21-60 years) was most affected by 45 (81.81%) DENV cases and the prevalent serotype was DENV-2 in singly and DENV-1 and DENV-2 in combination. The study's serotyping data might signify the early detection and identification of circulating serotypes, which provides valuable insights to clinicians for managing dengue infections. Hence, continuous epidemiological surveillance of DENV in the area is essential to anticipate future heterologous infections and their impact on healthcare. Early detection and vigilant monitoring of patients are crucial for identifying the circulating serotypes of dengue virus, facilitating subsequent epidemiological studies and disease control strategies.

印度恰蒂斯加尔邦巴斯塔尔地区登革热流行和血清型:一项横断面研究
登革热病毒是引起全球公共卫生关注的一种重要的再出现虫媒病毒。城市化、人口增长、人口流动、水获取和储存方式都有助于其传播。这项基于医院的横断面研究旨在确定恰蒂斯加尔邦巴斯塔尔地区的登革热感染和流行情况。采集患者血样,根据发热时间进行非结构蛋白1 (NS1)抗原和免疫球蛋白M (IgM)抗体检测。对NS1阳性病例进行RT-PCR分型。在采集的2223份样本中,NS1筛查2041份,IgM筛查182份;其中,NS1阳性55例(2.70%),IgM阳性23例(12.63%)。登革热总阳性78例(3.51%);然而,按性别划分,男性和女性登革热阳性病例分别为45例和33例。NS1阳性55例(70.51%),IgM阳性23例(29.49%)。78例病例中,4例NS1和2例IgM表现出预警症状,其余病例表现为无预警症状。55例NS1阳性病例中,年龄层(21 ~ 60岁)DENV发病最多,45例(81.81%),以DENV-2单一型和DENV-1与DENV-2合并型为主。该研究的血清分型数据可能意味着早期发现和识别流行的血清型,这为临床医生管理登革热感染提供了有价值的见解。因此,对该地区DENV的持续流行病学监测对于预测未来的异源感染及其对卫生保健的影响至关重要。早期发现和警惕监测患者对于确定登革热病毒的流行血清型、促进随后的流行病学研究和疾病控制战略至关重要。
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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
108
审稿时长
>12 weeks
期刊介绍: Canadian Journal of Infectious Diseases and Medical Microbiology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to infectious diseases of bacterial, viral and parasitic origin. The journal welcomes articles describing research on pathogenesis, epidemiology of infection, diagnosis and treatment, antibiotics and resistance, and immunology.
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