Bioactive Glass Graft vs Allograft in Benign Bone Lesions: A Retrospective Comparative Study.

IF 1.6 4区 医学 Q3 ORTHOPEDICS
Mustafa Alper Incesoy, Murat Sarikas, Hakan Batuhan Kaya, Ahmet Durcan Yavuz, Bilal Sulak, Asena Ayca Ozdemir, Ali Can Ozarslan, Gokcer Uzer, Fatih Yıldız, Sevil Yucel, Volkan Gurkan
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引用次数: 0

Abstract

Background: Bioactive glass (BG) is a promising alternative to conventional autogenous and allogeneic bone grafts with osteoconductive, osteoinductive, and antimicrobial properties. The effects of its use in comparison to allograft in the context of benign bone lesions remain less explored.

Purpose: We sought to compare the efficacy of 45S5 BG granules to allograft in treating benign bone lesions.

Methods: This retrospective study compared the outcomes of 45S5 BG granules and allograft bone in 42 patients undergoing curettage for benign bone lesions. Patients were divided into 2 groups based on the graft material used (n = 21 in each group). Radiological evaluation using the modified Neer classification and functional assessment using the Musculoskeletal Tumor Society (MSTS) score were performed. Complications and time to return to previous activity levels were also recorded.

Results: No significant differences were found between the BG and allograft groups in terms of postoperative Neer scores, postoperative MSTS scores, complication rates, or time to return to previous activity levels. Both groups showed significant improvement in MSTS scores over time, although improvement in MSTS scores for both groups did not reach the minimal clinically important difference, suggesting that the observed changes may not be clinically significant.

Conclusion: This retrospective study found that BG demonstrated comparable efficacy to allograft cancellous bone in the treatment of benign bone lesions, suggesting that it may serve as a suitable alternative. Further study should focus on longer-term follow-up and larger sample sizes to further elucidate the role of BG in the management of these lesions.

生物活性玻璃移植物与同种异体移植物治疗良性骨病变的回顾性比较研究。
背景:生物活性玻璃(BG)具有骨导电性、骨诱导性和抗菌性,是传统自体和异体骨移植物的一种很有前途的替代品。与同种异体骨移植相比,其在良性骨病变中的应用效果尚不明确。目的:比较45S5 BG颗粒与同种异体骨移植治疗良性骨病变的疗效。方法:回顾性比较45S5 BG颗粒和同种异体骨移植在42例良性骨病变刮除术中的效果。根据所使用的移植物材料将患者分为两组(每组21例)。采用改良的Neer分类进行放射学评估,使用肌肉骨骼肿瘤学会(MSTS)评分进行功能评估。同时记录并发症和恢复到以前活动水平的时间。结果:BG组和同种异体移植物组在术后Neer评分、术后MSTS评分、并发症发生率或恢复到先前活动水平的时间方面无显著差异。随着时间的推移,两组的MSTS评分均有显著改善,但两组的MSTS评分改善均未达到临床重要差异的最小值,提示观察到的变化可能不具有临床意义。结论:本回顾性研究发现BG与同种异体松质骨移植治疗良性骨病变的疗效相当,提示BG可能是一种合适的替代方案。进一步的研究应侧重于长期随访和更大的样本量,以进一步阐明BG在这些病变管理中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hss Journal
Hss Journal Medicine-Surgery
CiteScore
3.90
自引率
0.00%
发文量
42
期刊介绍: The HSS Journal is the Musculoskeletal Journal of Hospital for Special Surgery. The aim of the HSS Journal is to promote cutting edge research, clinical pathways, and state-of-the-art techniques that inform and facilitate the continuing education of the orthopaedic and musculoskeletal communities. HSS Journal publishes articles that offer contributions to the advancement of the knowledge of musculoskeletal diseases and encourages submission of manuscripts from all musculoskeletal disciplines.
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