Vitamin D status as a laboratory marker of whole spectrum of severity of osteoarthritis of knee.

Abstract

Objective: Aim: The aim of our research is to examine any relationship between vitamin D status and knee osteoarthritis.

Patients and methods: Materials and Methods: A specimen of 160 individuals presented to medical services in outpatient doctor's office were recruited into evaluations 80 participants with established diagnosis of osteoarthritis of knee chosen as cases and 80 participants without clinical and radiological evidence of knee joint osteoarthritis chosen as controls, both were assessed by meticulous clinical and rheumatologic examination, radiological assessment, and vitamin D quantification. Diagnosis of cases was verified in accordance with American college of rheumatology criteria, for whom both pain and radiological severity were measured.

Results: Results: mean age is 69.2570, 96 females, 64 males. F: M ratio is 1.5:1, 85 had subnormal vitamin D while 75 had normal vitamin D level. Majority who were vitamin D insufficient belong to cases 83.5%. Majority of those who have adequate vitamin D level related to control group with significant association P-value 0.0001. Most of cases who were vitamin D insufficient 60 out of 71 have grade 3 and 4 kellegren-Lawrence score of radiological severity with significant association where p-value 0.001, 14 out of 71 and 50 out of 71 case who have vitamin D inadequacy suffering from moderate and severe pain by visual analogue scale subsequently with significant association P value 0.001.

Conclusion: Conclusions: vitamin D status had substantial relation with various aspects of severity and perhaps worsening of knee osteoarthritis, emphasizing necessity of promoting the vitamin D quantification in those patients.