Brain tissue oxygen combined with intracranial pressure monitoring in patients with severe traumatic brain injury: An updated systematic review and meta-analysis following the OXY-TC trial.

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY
Yu Chang, Chia-En Wong, Hao-Hsiang Hsu, Kuan-Yu Chi, Jung-Shun Lee, Yen-Ta Huang, Chih-Yuan Huang
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引用次数: 0

Abstract

Introduction: Severe traumatic brain injury (TBI) is associated with high mortality and long-term disability. Effective TBI management, aimed at minimizing secondary brain damage, requires constant monitoring of intracranial pressure (ICP) with or without brain tissue oxygen pressure (PbtO2). The recent OXY-TC trial suggested that combined ICP + PbtO2 monitoring does not improve the 6-month neurological outcomes, prompting a meta-analysis to reassess the clinical role of PbtO2 monitoring.

Methods: We conducted systematic review and meta-analysis by searching the PubMed, Medline, and Cochrane databases for randomized controlled trials and prospective studies on adult severe TBI patients, comparing clinical outcomes of ICP monitoring alone versus ICP + PbtO2 monitoring. Data extraction and quality assessments were performed independently by two reviewers. Meta-analyses were conducted using a random-effects model, focusing on 6-month mortality and favorable functional outcomes.

Results: Six studies met the inclusion criteria. The ICP + PbtO2 group is more likely to have favorable outcomes (OR: 1.39, 95% CI: 1.01-1.92, I2 = 0%) 6 months following TBI. There were no statistically significant differences in the 6-month mortality (odds ratio, OR: 0.75, 95% confidence interval, CI: 0.52-1.10; I2 = 0%).

Conclusion: Our research findings partially align with the OXY-TC trial regarding the primary endpoint, demonstrating that brain tissue oxygen-guided therapy does not significantly reduce mortality rates in TBI patients 6 months post-injury. However, in contrast to the OXY-TC trial, we observed that the PbtO2 monitoring group showed a significantly higher proportion of favorable outcomes.

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来源期刊
World neurosurgery
World neurosurgery CLINICAL NEUROLOGY-SURGERY
CiteScore
3.90
自引率
15.00%
发文量
1765
审稿时长
47 days
期刊介绍: World Neurosurgery has an open access mirror journal World Neurosurgery: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The journal''s mission is to: -To provide a first-class international forum and a 2-way conduit for dialogue that is relevant to neurosurgeons and providers who care for neurosurgery patients. The categories of the exchanged information include clinical and basic science, as well as global information that provide social, political, educational, economic, cultural or societal insights and knowledge that are of significance and relevance to worldwide neurosurgery patient care. -To act as a primary intellectual catalyst for the stimulation of creativity, the creation of new knowledge, and the enhancement of quality neurosurgical care worldwide. -To provide a forum for communication that enriches the lives of all neurosurgeons and their colleagues; and, in so doing, enriches the lives of their patients. Topics to be addressed in World Neurosurgery include: EDUCATION, ECONOMICS, RESEARCH, POLITICS, HISTORY, CULTURE, CLINICAL SCIENCE, LABORATORY SCIENCE, TECHNOLOGY, OPERATIVE TECHNIQUES, CLINICAL IMAGES, VIDEOS
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