Meta-Analysis of Tonometer Correction Formulae to Determine True Normal Intraocular Pressures Across a Diverse Range of Species.

IF 1.7 4区 农林科学 Q2 VETERINARY SCIENCES
Andrew C Lewin, Caroline Rose, Xiaojuan Zhu, Paul E Miller
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引用次数: 0

Abstract

Objective: To utilize previously published tonometer correction formulae to investigate whether true intraocular pressure (IOP) is relatively conserved across a diverse range of vertebrate species.

Animals studied: Tonometer correction formulae for 21 species.

Procedures: A literature search was performed to identify prior studies containing correction formulae for non-invasive tonometers used in normal animal and human subjects. In all cases, direct manometry was compared to non-invasive tonometry values. Where necessary, multiple correction regression formulae were combined to generate a single representative formula using a meta-analysis generic inverse variance method. A subsequent literature search was then performed to collect uncorrected IOP values of normal animals and humans using a variety of non-invasive tonometers. These IOP values were then corrected using the relevant correction formula.

Results: Sixty-five tonometer correction formulae and 104 studies containing IOP values in normal animals and humans acquired using non-invasive tonometry met the inclusion criteria. Corrected IOP values were calculated for 21 species using 13 types of non-invasive tonometers. Overall corrected and uncorrected mean IOP values were typically within a range of 10 to 25 mmHg (corrected: 16/21 species, uncorrected: 14/21 species). Differences between overall mean corrected and uncorrected IOP values ranged from 0.2 to 15.3 mmHg with an average of 6.1 mmHg difference.

Conclusions: True normal IOP is relatively conserved across a diverse range of vertebrate species despite uncorrected values from individual tonometers suggesting otherwise. Maintaining true IOP between 10 and 25 mmHg appears to be important in ocular physiology in many vertebrates.

测定不同物种真实正常眼压的血压计校正公式的meta分析。
目的:利用先前发表的眼压计校正公式来研究真实眼压(IOP)在不同脊椎动物物种中是否相对保守。研究动物:21种眼压计校正公式。程序:进行文献检索,以确定先前的研究包含用于正常动物和人类受试者的非侵入性血压计的校正公式。在所有病例中,将直接测压与非侵入性测压值进行比较。必要时,使用元分析通用反方差法,将多个修正回归公式合并生成一个单一的代表性公式。随后进行文献检索,使用各种无创眼压计收集正常动物和人类的未校正眼压值。然后使用相关的校正公式对这些IOP值进行校正。结果:65个眼压计校正公式和104个使用无创眼压计获得的正常动物和人类眼压值的研究符合纳入标准。使用13种非侵入性眼压计计算21种动物的校正眼压值。总体校正和未校正的平均IOP值通常在10至25 mmHg之间(校正后:16/21种,未校正后:14/21种)。总体平均校正与未校正IOP值之间的差异范围为0.2 ~ 15.3 mmHg,平均差异为6.1 mmHg。结论:尽管个体眼压计的未校正值表明不同情况,但在不同的脊椎动物物种中,真正正常的IOP是相对保守的。在许多脊椎动物的眼生理学中,将真正的IOP维持在10 - 25 mmHg之间似乎很重要。
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来源期刊
Veterinary ophthalmology
Veterinary ophthalmology 农林科学-兽医学
CiteScore
2.70
自引率
37.50%
发文量
82
审稿时长
12-24 weeks
期刊介绍: Veterinary Ophthalmology is a peer-reviewed, international journal that welcomes submission of manuscripts directed towards academic researchers of veterinary ophthalmology, specialists and general practitioners with a strong ophthalmology interest. Articles include those relating to all aspects of: Clinical and investigational veterinary and comparative ophthalmology; Prospective and retrospective studies or reviews of naturally occurring ocular disease in veterinary species; Experimental models of both animal and human ocular disease in veterinary species; Anatomic studies of the animal eye; Physiological studies of the animal eye; Pharmacological studies of the animal eye.
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