Higher Time to Peak after Stent Implantation in Symptomatic High-Grade Intracranial Atherosclerotic Stenosis is Related to In-Stent Restenosis.

IF 3.8 2区 医学 Q1 CLINICAL NEUROLOGY
Longhui Zhang, Haoyu Zhu, Yupeng Zhang, Fangguang Chen, Dapeng Sun, Yufan Liu, Chuhan Jiang, Zhongrong Miao, Baixue Jia
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Abstract

Little is known about the association between periprocedural hemodynamics and in-stent restenosis (ISR) following stent implantation in patients with symptomatic intracranial atherosclerotic stenosis (ICAS). This study aims to identify periprocedural hemodynamics that may be associated with ISR. Subjects were selected from the NOVA trial (The First-in-man Trial Evaluating the Safety and Efficacy of the NOVA Intracranial Stent Trial). ISR was defined as greater than 50% stenosis of the luminal diameter within or immediately adjacent to (within 5 mm) the implanted stent. Periprocedural hemodynamics, including cerebral blood flow, cerebral blood volume, mean transit time, and time to peak (TTP), were derived from the time-density curve generated from digital subtraction angiography using the fast Fourier transform algorithm. Of the 263 patients enrolled in the NOVA trial, 176 with symptomatic high-grade ICAS who underwent stent implantation were included in this study. Of these, 35 (19.9%) were diagnosed with ISR at the one-year follow-up. No significant differences in pre-procedure hemodynamics were observed between stent groups and between the ISR groups and the non-ISR group. Higher post-procedure TTP (OR, 1.95; 95% CI, 1.26-3.02), the use of bare-metal stents (OR, 5.40; 95% CI, 2.21-13.19), and higher post-procedure residual stenosis (OR, 1.08; 95% CI, 1.03-1.13) were independent factors associated with ISR. Higher post-procedure TTP, the use of bare-metal stents, and higher post-procedure residual stenosis were independent factors associated with ISR. The combined use of periprocedural hemodynamics and clinical factors may help predict ISR in patients with symptomatic high-grade ICAS.

有症状的高级别颅内动脉粥样硬化性狭窄患者支架植入术后峰值时间延长与支架内再狭窄有关。
对于症状性颅内动脉粥样硬化性狭窄(ICAS)患者支架植入术后围手术期血流动力学与支架内再狭窄(ISR)之间的关系知之甚少。本研究旨在确定可能与ISR相关的围手术期血流动力学。受试者从NOVA试验(评估NOVA颅内支架安全性和有效性的首次人体试验)中选择。ISR被定义为植入支架内或紧靠支架(5mm以内)腔径狭窄超过50%。采用快速傅立叶变换算法从数字减影血管造影生成的时间-密度曲线中获得围手术期血流动力学,包括脑血流量、脑血容量、平均传输时间和到达峰值时间(TTP)。在参加NOVA试验的263例患者中,有176例有症状的高级别ICAS患者接受了支架植入。其中,35人(19.9%)在一年的随访中被诊断为ISR。术前血流动力学在支架组之间以及ISR组和非ISR组之间没有显著差异。术后TTP增高(OR, 1.95;95% CI, 1.26-3.02),裸金属支架的使用(OR, 5.40;95% CI, 2.21-13.19),术后残留狭窄较高(OR, 1.08;95% CI, 1.03-1.13)是与ISR相关的独立因素。较高的术后TTP、裸金属支架的使用和较高的术后残留狭窄是与ISR相关的独立因素。联合应用围手术期血流动力学和临床因素可能有助于预测有症状的高级别ICAS患者的ISR。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Translational Stroke Research
Translational Stroke Research CLINICAL NEUROLOGY-NEUROSCIENCES
CiteScore
13.80
自引率
4.30%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Translational Stroke Research covers basic, translational, and clinical studies. The Journal emphasizes novel approaches to help both to understand clinical phenomenon through basic science tools, and to translate basic science discoveries into the development of new strategies for the prevention, assessment, treatment, and enhancement of central nervous system repair after stroke and other forms of neurotrauma. Translational Stroke Research focuses on translational research and is relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons.
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