The utility of the new category by number of stations for lymph nodal involvement in non-small cell lung cancer.

IF 2.5 3区医学 Q3 ONCOLOGY

Oncology Pub Date : 2025-03-21 DOI:10.1159/000545002

Nozomu Motono, Takaki Mizoguchi, Masahito Ishikawa, Shun Iwai, Yoshihito Iijima, Hidetaka Uramoto

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引用次数: 0

Abstract

Introduction: In the nineth edition of the TNM staging system, the new nodal involvement (N) subcategories to N2 for single-station involvement (N2a) and multiple-station involvement (N2b) has been adopted Although there are significant differences in survival rates for each group of pN categories in the nineth edition, it can be assumed that survival rates in pN1 and pN2a are relatively similar.

Methods: We retrospectively evaluated the utility of the new category by number of stations, such as None, Single station, and Multiple station for pN in 1000 NSCLC patients treated by pulmonary resection.

Result: Survival rates were significantly different in among None, Single station, and Multiple station (5-year RFS: None;79.6%, Single station;47.3%, Multiple station;24.2%, all groups p<0.01. 8-year OS: None;78.7%, Single station;65.2%, Multiple station;33.6%, all groups p<0.01). There were significant differences among each group categorized by number of pN station in multivariate analysis for RFS (None vs Single station; P<.01, None vs Multiple station; P<.01, Single station vs Multiple station; P<.01). There were significant differences among each group categorized by number of pN station in multivariate analysis for OS (None vs Single station; P=.04, None vs Multiple station; P<.01, Single station vs Multiple station; P<.01).

Conclusion: There were significant differences among None, Single station, and Multiple station in each survival curves, and in multivariate analysis for both RFS and OS. This category by number of pN station without dependence of location for lymph nodal involvement might be the new classification of lymph node involvement.

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来源期刊

Oncology 医学-肿瘤学

CiteScore

6.00

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.