Synergistic Strategies for Lung Cancer Immunotherapy: Combining Phytochemicals and Immune-Checkpoint Inhibitors.

IF 6.3 2区 医学 Q1 CHEMISTRY, MEDICINAL
Quan Gao, Hao Wu, Zhengjun Li, Zijing Yang, Lin Li, Xueni Sun, Qibiao Wu, Xinbing Sui
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Abstract

Lung cancer remains one of the most widespread and deadliest malignant tumors globally, with a particularly high mortality rate among all cancers. Recently, immunotherapy, particularly immune checkpoint inhibitors (ICIs), has emerged as a crucial treatment strategy for lung cancer patients, following surgical intervention, radiotherapy, chemotherapy, and targeted drug therapies. However, the therapeutic limitations are caused owing to their low response rate and undesirable side effects such as immune-related pneumonitis. Therefore, developing new strategies to improve the efficacy of ICIs while minimizing immune-related adverse events will be crucial for cancer immunotherapy. The tumor immune microenvironment plays a significant role in the success of lung cancer immunotherapy, and the immunosuppressive characteristics of the immune microenvironment are one of the major obstacles to the poor immunotherapeutic effect. Phytochemicals, naturally occurring compounds in plants, have shown promise in enhancing cancer immunotherapy by remodeling the immunosuppressive microenvironment, offering the potential to increase the efficacy of ICIs. Therefore, this review summarizes the associated mechanisms of phytochemicals remodeling the immunosuppressive microenvironment in lung cancer. Additionally, the review will focus on the synergistic effects of combining phytochemicals with ICIs, aiming to improve anticancer efficacy and reduce side effects, which may hopefully offer novel strategies to overcome current limitations in immunotherapy.

肺癌免疫治疗的协同策略:结合植物化学物质和免疫检查点抑制剂。
肺癌仍然是全球最普遍和最致命的恶性肿瘤之一,在所有癌症中死亡率特别高。最近,免疫疗法,特别是免疫检查点抑制剂(ICIs),已成为肺癌患者继手术干预、放疗、化疗和靶向药物治疗之后的重要治疗策略。然而,由于其低反应率和不良副作用,如免疫相关性肺炎,导致治疗局限性。因此,开发新的策略来提高ICIs的疗效,同时最大限度地减少免疫相关的不良事件,将是癌症免疫治疗的关键。肿瘤免疫微环境对肺癌免疫治疗的成功起着重要的作用,而免疫微环境的免疫抑制特性是导致免疫治疗效果不佳的主要障碍之一。植物化学物质是植物中天然存在的化合物,已显示出通过重塑免疫抑制微环境来增强癌症免疫治疗的前景,为提高ICIs的疗效提供了潜力。因此,本文就植物化学物质重塑肺癌免疫抑制微环境的相关机制进行综述。此外,本文将重点讨论植物化学物质与ICIs联合使用的协同效应,旨在提高抗癌疗效和减少副作用,有望为克服目前免疫治疗的局限性提供新的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Phytotherapy Research
Phytotherapy Research 医学-药学
CiteScore
12.80
自引率
5.60%
发文量
325
审稿时长
2.6 months
期刊介绍: Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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