The Structure and Functional Changes of Thyroid in Severe Acute Pancreatitis Rats.

IF 1.9 4区医学 Q3 PHYSIOLOGY

Physiological research Pub Date : 2025-03-24

B Yang, H Qiao, Y Liu, X Wang, W Peng

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引用次数: 0

Abstract

Severe acute pancreatitis (SAP) is associated with metabolic disorders, hypocalcemia, and multiple organ failure. The objective of this study was to investigate changes in thyroid ultrastructure and function in rats with SAP and to provide a theoretical basis for the clinical treatment of thyroid injury in patients with SAP. 64 male SPF Wistar rats were randomly divided into the SAP group and the control group. Pancreatic enzymatic indicators and thyroid hormones were detected, pathology scores were evaluated, and morphological changes were observed under light microscopy and transmission electron microscopy (TEM) in both groups. The serum levels of triiodothyronine (T3), tetraiodothyronine (T4) and Ca2+ were significantly lower in the SAP group than in the control group (P<0.05), whereas the level of calcitonin (CT) was significantly higher than that in the control group (P<0.05). The thyroid structure (pathology and electron microscopy) of the SAP rats was seriously damaged and worsened over time. SAP can cause thyroid injury through a variety of mechanisms, which can also retroact to pancreatitis to aggravate the inflammatory response. This study may have theoretical significance for basic research on SAP. Key words Severe acute pancreatitis, Thyroid, Structure and functional changes, Transmission electron microscopy.

本刊更多论文

重症急性胰腺炎大鼠甲状腺结构和功能的变化。

严重急性胰腺炎（SAP）与代谢紊乱、低钙血症和多器官衰竭有关。本研究旨在探讨SAP大鼠甲状腺超微结构和功能的变化，为SAP患者甲状腺损伤的临床治疗提供理论依据。选取雄性SPF级Wistar大鼠64只，随机分为SAP组和对照组。检测两组胰腺酶指标、甲状腺激素水平，评估病理评分，光镜、透射电镜观察两组胰腺形态学变化。SAP组血清三碘甲状腺原氨酸（T3）、四碘甲状腺原氨酸（T4）和Ca2+水平显著低于对照组(P

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来源期刊

Physiological research 医学-生理学

CiteScore

4.00

自引率

4.80%

发文量

108

审稿时长

3 months

期刊介绍： Physiological Research is a peer reviewed Open Access journal that publishes articles on normal and pathological physiology, biochemistry, biophysics, and pharmacology. Authors can submit original, previously unpublished research articles, review articles, rapid or short communications. Instructions for Authors - Respect the instructions carefully when submitting your manuscript. Submitted manuscripts or revised manuscripts that do not follow these Instructions will not be included into the peer-review process. The articles are available in full versions as pdf files beginning with volume 40, 1991. The journal publishes the online Ahead of Print /Pre-Press version of the articles that are searchable in Medline and can be cited.