Assessing ¹⁸F-FDG PET/CT Uptake and its Correlation with Molecular Biomarkers in Penile Cancer.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Nuclear Medicine and Molecular Imaging Pub Date : 2025-04-01 Epub Date: 2024-08-30 DOI:10.1007/s13139-024-00877-y

André Salazar, Eduardo Paulino Júnior, Diego F Sánchez, Aízis Tatiane Santos Gonçalves, Renata Toscano Simões, Raul Silva-Filho, João V S Raimundo, Yuri V C Soares, Matheus L Marinho, Antonio L Cubilla, Marcelo Mamede

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引用次数: 0

Abstract

Background: Penile Cancer is a rare and aggressive disease. Related to complex metabolic processes.

Objective: This study investigates the effectiveness of ¹⁸F-FDG PET/CT as a noninvasive method in evaluating penile cancer patients, focusing on the correlation between tissue expression of key tumor markers involved in glucose metabolism and proliferation, and the uptake of ¹⁸F-FDG.

Methods: Fifty-one patients were selected and underwent ¹⁸F-FDG PET/CT-based staging. Semiquantitative analysis was performed using the maximum standardized uptake value (SUV_max) and volumetric SUV (SUV_2SD). Tissue expression analysis of GLUT-1, hexokinase-II, Ki67, p16, and p53 was performed by tissue microarray. PCR evaluated HPV DNA.

Results: Warty SCC showed the highest SUV value and significant differences in SUV_max (p=0.015). Higher SUV_max and SUV_2SD values were observed in grade 3 tumors. In typical invasive SCC, grade 3, HPV+, p16-negative, p53-negative, GLUT-1 i-3, and HK-II i-3 tumors showed a higher mean SUV. The Ki-67 value significantly differed for grade 3 tumors (p=0.001) and HK-II i-1 tumors (p=0.036). Ki-67 positivity was also higher in HPV-, p16 i-2, p53 i-3, and GLUT-1 i-3 tumors; none of the differences were statistically significant.

Conclusions: The study highlights correlations between the uptake of ¹⁸F-FDG and the expression of markers associated with glycolytic metabolism in penile cancer. It suggests a potential trend where increased expression of glucose transport markers is linked to higher histological grades and Ki-67 expression. There were no significant differences regarding HPV positivity, demonstrating the complexity of penile cancer molecular biology and need more studies with a higher number of patients.

Graphical abstract:

Supplementary information: The online version contains supplementary material available at 10.1007/s13139-024-00877-y.

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背景：阴茎癌是一种罕见的侵袭性疾病：阴茎癌是一种罕见的侵袭性疾病。与复杂的代谢过程有关：本研究探讨了 18F-FDG PET/CT 作为一种无创方法评估阴茎癌患者的有效性，重点关注参与葡萄糖代谢和增殖的关键肿瘤标志物的组织表达与 18F-FDG 摄取之间的相关性：方法：选取 51 例患者进行基于 18F-FDG PET/CT 的分期。采用最大标准化摄取值（SUVmax）和容积SUV（SUV2SD）进行半定量分析。通过组织芯片对 GLUT-1、hexokinase-II、Ki67、p16 和 p53 进行了组织表达分析。PCR 评估了 HPV DNA：结果：疣状 SCC 的 SUV 值最高，且 SUVmax 有显著差异（p=0.015）。3级肿瘤的SUVmax和SUV2SD值更高。在典型的浸润性 SCC 中，3 级、HPV+、p16 阴性、p53 阴性、GLUT-1 i-3 和 HK-II i-3 肿瘤的平均 SUV 值较高。3级肿瘤（p=0.001）和HK-II i-1肿瘤（p=0.036）的Ki-67值有明显差异。在HPV-、p16 i-2、p53 i-3和GLUT-1 i-3肿瘤中，Ki-67阳性率也较高；差异均无统计学意义：本研究强调了阴茎癌中 18F-FDG 摄取与糖代谢相关标记物表达之间的相关性。它表明了一种潜在的趋势，即葡萄糖转运标记物表达的增加与较高的组织学分级和Ki-67表达有关。人类乳头瘤病毒（HPV）阳性方面没有明显差异，这表明阴茎癌分子生物学的复杂性，需要对更多患者进行更多研究：在线版本包含补充材料，可在10.1007/s13139-024-00877-y上获取。

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来源期刊

Nuclear Medicine and Molecular Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.20

自引率

7.70%

发文量

期刊介绍： Nuclear Medicine and Molecular Imaging (Nucl Med Mol Imaging) is an official journal of the Korean Society of Nuclear Medicine, which bimonthly publishes papers on February, April, June, August, October, and December about nuclear medicine and related sciences such as radiochemistry, radiopharmacy, dosimetry and pharmacokinetics / pharmacodynamics of radiopharmaceuticals, nuclear and molecular imaging analysis, nuclear and molecular imaging instrumentation, radiation biology and radionuclide therapy. The journal specially welcomes works of artificial intelligence applied to nuclear medicine. The journal will also welcome original works relating to molecular imaging research such as the development of molecular imaging probes, reporter imaging assays, imaging cell trafficking, imaging endo(exo)genous gene expression, and imaging signal transduction. Nucl Med Mol Imaging publishes the following types of papers: original articles, reviews, case reports, editorials, interesting images, and letters to the editor. The Korean Society of Nuclear Medicine (KSNM) KSNM is a scientific and professional organization founded in 1961 and a member of the Korean Academy of Medical Sciences of the Korean Medical Association which was established by The Medical Services Law. The aims of KSNM are the promotion of nuclear medicine and cooperation of each member. The business of KSNM includes holding academic meetings and symposia, the publication of journals and books, planning and research of promoting science and health, and training and qualification of nuclear medicine specialists.