Osteoimmunology in Osteoarthritis: Unraveling the Interplay of Immunity, Inflammation, and Joint Degeneration.

IF 4.2 2区 医学 Q2 IMMUNOLOGY
Journal of Inflammation Research Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI:10.2147/JIR.S514002
Kangyi Hu, Min Song, Ting Song, Xiao Jia, Yongjia Song
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引用次数: 0

Abstract

Osteoarthritis (OA) is a degenerative joint disease influenced by multiple factors, with its etiology arising from intricate interactions among mechanical stress, inflammatory processes, and disruptions in bone metabolism. Recent research in bone immunology indicates that immune-mediated mechanisms significantly contribute to the progression of OA, highlighting the interactions among immune cells, cytokine networks, and bone components. Immune cells interact with osteoclasts, osteoblasts, and chondrocytes in a variety of ways. These interactions foster a pro-inflammatory microenvironment, contributing to cartilage breakdown, synovial inflammation, and the sclerosis of subchondral bone. In this article, we present a comprehensive review of bone immunology in OA, focusing on the critical role of immune cells and their cytokine-mediated feedback loops in the pathophysiology of OA. In addition, we are exploring novel therapeutic strategies targeting bone immune pathways, including macrophage polarization, T-cell differentiation, and stem cell therapy to restore the metabolic balance between immunity and bone. By integrating cutting-edge research in bone immunology, this review integrates the latest advancements in bone immunology to construct a comprehensive framework for unraveling the pathogenesis of OA, laying a theoretical foundation for the development of innovative precision therapies.

骨关节炎的骨免疫学:揭示免疫、炎症和关节退变的相互作用。
骨关节炎(OA)是一种受多种因素影响的退行性关节疾病,其病因是机械应力、炎症过程和骨代谢中断之间复杂的相互作用。最近的骨免疫学研究表明,免疫介导的机制在骨关节炎的进展中起着重要作用,突出了免疫细胞、细胞因子网络和骨成分之间的相互作用。免疫细胞以多种方式与破骨细胞、成骨细胞和软骨细胞相互作用。这些相互作用形成促炎微环境,导致软骨破裂、滑膜炎症和软骨下骨硬化。在这篇文章中,我们介绍了骨免疫学在OA中的全面综述,重点关注免疫细胞及其细胞因子介导的反馈回路在OA病理生理中的关键作用。此外,我们正在探索针对骨免疫通路的新治疗策略,包括巨噬细胞极化、t细胞分化和干细胞治疗,以恢复免疫和骨之间的代谢平衡。本文通过整合骨免疫学前沿研究,整合骨免疫学最新进展,构建一个全面揭示OA发病机制的框架,为开发创新精准疗法奠定理论基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Inflammation Research
Journal of Inflammation Research Immunology and Microbiology-Immunology
CiteScore
6.10
自引率
2.20%
发文量
658
审稿时长
16 weeks
期刊介绍: An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.
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