Tuan Huu Ngoc Nguyen, Huy Quang Nguyen, Ngan Thi Thu Le, Han To Ngoc Nguyen, Hung Cao Dinh, Tam Ngoc Nguyen, Ha Minh Nguyen
{"title":"Trends of Colistin MIC Among <i>Acinetobacter Baumannii</i> and <i>Pseudomonas aeruginosa</i> at a First-Class Hospital in Vietnam.","authors":"Tuan Huu Ngoc Nguyen, Huy Quang Nguyen, Ngan Thi Thu Le, Han To Ngoc Nguyen, Hung Cao Dinh, Tam Ngoc Nguyen, Ha Minh Nguyen","doi":"10.1155/jotm/6165665","DOIUrl":null,"url":null,"abstract":"<p><p><b>Introduction:</b> <i>A. baumannii</i> and <i>P. aeruginosa</i> belong to the multidrug-resistant Gram-negative bacteria group, posing significant challenges in treatment. Colistin is considered the last-line antibiotic for treating this bacterium. It is essential to determine the minimum inhibitory concentration (MIC) to adjust the appropriate dosage. <b>Method:</b> A cross-sectional descriptive study using data from January 2020 to December 2024 was conducted. <b>Results:</b> The infections caused by <i>A. baumannii</i> and <i>P. aeruginosa</i> showed an increasing trend over the years, accounting for 17.4% and 9.6% of common multidrug-resistant Gram-negative bacteria, respectively. <i>A. baumannii</i> exhibited higher resistance rates than <i>P. aeruginosa</i> with multiple tested antibiotics. Although no Colistin-resistant strains were observed for either bacterium of interest during the observation period, both bacteria of interest showed a statistically significant change during the survey period (<i>p</i> < 0.05). In addition, the MIC value of ≤ 0.75 μg/mL was the most prevalent over 80% from 2020 to 2021, but its percentage declined strongly by 60%-65% in the next 3 years (<i>p</i> < 0.0001). Meanwhile, the MIC value of 1.0 μg/mL became the most common over 70% with a statistically significant difference (<i>p</i> < 0.0001). Regarding the MIC value based on infection types, the MIC value for <i>P. aeruginosa</i> causing septicemia was considerably concentrated at 1.0 μg/mL at 84.6%, while its percentage was lower in <i>A. baumannii</i> at 37.9% (<i>p</i> < 0.0001). Looking into MIC values based on carbapenem-resistant proportions, the MIC values from 1.0 to 2.0 μg/mL were higher in imipenem-resistant strains of both bacteria of interest compared with nonresistant strains (<i>p</i> < 0.0001). This difference was also observed in meropenem-resistant <i>A. baumannii</i> but was not demonstrated in <i>P. aeruginosa</i>. <b>Conclusions:</b> Although no colistin-resistant strains were observed, <i>A. baumannii</i> and <i>P. aeruginosa</i> showed statistically significant changes in the most prevalent colistin MIC values, which have been approaching the resistance threshold over the years. It is essential to implement control measures of colistin usage before bacteria become completely resistant.</p>","PeriodicalId":17527,"journal":{"name":"Journal of Tropical Medicine","volume":"2025 ","pages":"6165665"},"PeriodicalIF":2.1000,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930383/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Tropical Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/jotm/6165665","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction:A. baumannii and P. aeruginosa belong to the multidrug-resistant Gram-negative bacteria group, posing significant challenges in treatment. Colistin is considered the last-line antibiotic for treating this bacterium. It is essential to determine the minimum inhibitory concentration (MIC) to adjust the appropriate dosage. Method: A cross-sectional descriptive study using data from January 2020 to December 2024 was conducted. Results: The infections caused by A. baumannii and P. aeruginosa showed an increasing trend over the years, accounting for 17.4% and 9.6% of common multidrug-resistant Gram-negative bacteria, respectively. A. baumannii exhibited higher resistance rates than P. aeruginosa with multiple tested antibiotics. Although no Colistin-resistant strains were observed for either bacterium of interest during the observation period, both bacteria of interest showed a statistically significant change during the survey period (p < 0.05). In addition, the MIC value of ≤ 0.75 μg/mL was the most prevalent over 80% from 2020 to 2021, but its percentage declined strongly by 60%-65% in the next 3 years (p < 0.0001). Meanwhile, the MIC value of 1.0 μg/mL became the most common over 70% with a statistically significant difference (p < 0.0001). Regarding the MIC value based on infection types, the MIC value for P. aeruginosa causing septicemia was considerably concentrated at 1.0 μg/mL at 84.6%, while its percentage was lower in A. baumannii at 37.9% (p < 0.0001). Looking into MIC values based on carbapenem-resistant proportions, the MIC values from 1.0 to 2.0 μg/mL were higher in imipenem-resistant strains of both bacteria of interest compared with nonresistant strains (p < 0.0001). This difference was also observed in meropenem-resistant A. baumannii but was not demonstrated in P. aeruginosa. Conclusions: Although no colistin-resistant strains were observed, A. baumannii and P. aeruginosa showed statistically significant changes in the most prevalent colistin MIC values, which have been approaching the resistance threshold over the years. It is essential to implement control measures of colistin usage before bacteria become completely resistant.
期刊介绍:
Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.