Trends of Colistin MIC Among Acinetobacter Baumannii and Pseudomonas aeruginosa at a First-Class Hospital in Vietnam.

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Journal of Tropical Medicine Pub Date : 2025-03-16 eCollection Date: 2025-01-01 DOI:10.1155/jotm/6165665
Tuan Huu Ngoc Nguyen, Huy Quang Nguyen, Ngan Thi Thu Le, Han To Ngoc Nguyen, Hung Cao Dinh, Tam Ngoc Nguyen, Ha Minh Nguyen
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引用次数: 0

Abstract

Introduction: A. baumannii and P. aeruginosa belong to the multidrug-resistant Gram-negative bacteria group, posing significant challenges in treatment. Colistin is considered the last-line antibiotic for treating this bacterium. It is essential to determine the minimum inhibitory concentration (MIC) to adjust the appropriate dosage. Method: A cross-sectional descriptive study using data from January 2020 to December 2024 was conducted. Results: The infections caused by A. baumannii and P. aeruginosa showed an increasing trend over the years, accounting for 17.4% and 9.6% of common multidrug-resistant Gram-negative bacteria, respectively. A. baumannii exhibited higher resistance rates than P. aeruginosa with multiple tested antibiotics. Although no Colistin-resistant strains were observed for either bacterium of interest during the observation period, both bacteria of interest showed a statistically significant change during the survey period (p < 0.05). In addition, the MIC value of ≤ 0.75 μg/mL was the most prevalent over 80% from 2020 to 2021, but its percentage declined strongly by 60%-65% in the next 3 years (p < 0.0001). Meanwhile, the MIC value of 1.0 μg/mL became the most common over 70% with a statistically significant difference (p < 0.0001). Regarding the MIC value based on infection types, the MIC value for P. aeruginosa causing septicemia was considerably concentrated at 1.0 μg/mL at 84.6%, while its percentage was lower in A. baumannii at 37.9% (p < 0.0001). Looking into MIC values based on carbapenem-resistant proportions, the MIC values from 1.0 to 2.0 μg/mL were higher in imipenem-resistant strains of both bacteria of interest compared with nonresistant strains (p < 0.0001). This difference was also observed in meropenem-resistant A. baumannii but was not demonstrated in P. aeruginosa. Conclusions: Although no colistin-resistant strains were observed, A. baumannii and P. aeruginosa showed statistically significant changes in the most prevalent colistin MIC values, which have been approaching the resistance threshold over the years. It is essential to implement control measures of colistin usage before bacteria become completely resistant.

越南某三甲医院鲍曼不动杆菌和铜绿假单胞菌黏菌素MIC变化趋势
鲍曼假单胞菌和铜绿假单胞菌属于多重耐药革兰氏阴性菌群,在治疗方面面临重大挑战。粘菌素被认为是治疗这种细菌的最后一线抗生素。确定最低抑菌浓度(MIC)以调整合适的剂量是必要的。方法:采用横断面描述性研究方法,使用2020年1月至2024年12月的数据。结果:鲍曼不动杆菌和铜绿假单胞菌的感染呈逐年上升趋势,分别占常见多重耐药革兰氏阴性菌的17.4%和9.6%。鲍曼假单胞菌对多种抗生素的耐药率高于铜绿假单胞菌。虽然在观察期间未观察到任何一种目的菌的耐粘菌素菌株,但在调查期间,两种目的菌的变化均有统计学意义(p < 0.05)。2020 - 2021年,MIC值≤0.75 μg/mL的比例最高,超过80%,但未来3年下降幅度为60% ~ 65% (p < 0.0001)。同时,MIC值1.0 μg/mL超过70%成为最常见的,差异有统计学意义(p < 0.0001)。从不同感染类型的MIC值来看,铜绿假单胞菌引起败血症的MIC值相当集中,为1.0 μg/mL,占84.6%,鲍曼假单胞菌的MIC值较低,为37.9% (p < 0.0001)。基于碳青霉烯耐药比例的MIC值,两种细菌亚胺培南耐药菌株的MIC值在1.0 ~ 2.0 μg/mL范围内均高于非耐药菌株(p < 0.0001)。这种差异在耐美罗培宁的鲍曼假单胞菌中也有发现,但在铜绿假单胞菌中没有发现。结论:虽然没有观察到粘菌素耐药菌株,但鲍曼假单胞菌和铜绿假单胞菌的最流行粘菌素MIC值变化具有统计学意义,这些值多年来一直接近耐药阈值。必须在细菌完全耐药之前实施使用粘菌素的控制措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
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