Dyspnea and dystussia in Parkinson's disease: patient-reported prevalence and determinants.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology Pub Date : 2025-03-22 DOI:10.1007/s00415-025-13008-0

Veerle A van de Wetering-van Dongen, Maarten J Nijkrake, Philip J van der Wees, Joanna IntHout, S K L Darweesh, Bastiaan R Bloem, Johanna G Kalf

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引用次数: 0

Abstract

Background: The prevalence of respiratory dysfunction in PD is unknown and a better understanding of determinants contributing to respiratory dysfunction is important to facilitate early recognition and treatment.

Objective: To examine the prevalence and determinants of self-reported symptoms of respiratory dysfunction among people with PD.

Methods: In a cross-sectional study, we administered a self-completed questionnaire among a sample of 939 persons with PD. Respiratory dysfunction was defined as experiencing at least one of the following symptoms: breathing difficulties, breathlessness/shortness of breath, tightening of the chest, frequent throat clearing, frequent coughing, or coughing difficulties. A principal component analysis (PCA) was used to define composite constructs of respiratory dysfunction. The association with participant-reported determinants was assessed using multivariable logistic regression models (with adjustment for pulmonary diseases and COVID-19 symptoms).

Results: The overall prevalence rate of respiratory dysfunction was 44% in persons with PD (42% after excluding pulmonary diseases or COVID-19). The PCA resulted in two constructs of respiratory dysfunction: 'dyspnea' and 'dystussia' (an impaired cough response), which together explained 68% of the total variance. Female sex (OR = 1.39), higher BMI kg/m² (OR = 1.04), longer disease duration (OR = 1.35), greater self-reported rigidity (OR = 1.16), previous pulmonary disease(s) (OR = 7.12), and anxiety (OR = 1.04) were independently associated with 'dyspnea'. Pulmonary disease(s) (OR = 1.81), COVID-19 symptoms (OR = 2.20), swallowing complaints (OR = 1.48), and speech complaints (OR = 1.02) were independently associated with 'dystussia'.

Conclusions: Dyspnea and dystussia are common manifestations of respiratory dysfunction among people with PD and deserves more awareness in clinical practice. A proactive screening for the determinants of dyspnea and dystussia may contribute to earlier recognition and treatment of respiratory dysfunction.

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来源期刊

Journal of Neurology 医学-临床神经学

CiteScore

10.00

自引率

5.00%

发文量

558

审稿时长

1 months

期刊介绍： The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.