Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-03-22 DOI:10.1038/s41372-025-02269-2

Caroline G Borden, Veronika Shabanova, Sarah N Taylor, Catherine O Buck

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引用次数: 0

Abstract

Objective: Characterize changes in neonatal energy metabolism hormones in first postnatal week.

Study design: Concentrations of leptin, adiponectin, insulin, resistin, and ghrelin were measured in cord and infant blood collected in the first postnatal week in a prospective cohort of term and preterm infants. Change over time in each hormone was modeled using linear mixed effects regression.

Result: Among 106 infants, 65 (61%) were preterm and 44 (42%) were exposed to diabetes (DM) in pregnancy. DM group had higher leptin [between group difference β 2.5 (95%CI: 1.72-3.70)] and resistin [β 1.5 (95%CI:1.14, 1.92)] and lower ghrelin [β 0.49] [95%CI: (0.32-0.76)] versus non-DM group. Preterm infants had lower adiponectin [β 0.80 (95%CI: 0.67-0.96)] versus term group. Insulin varied by DM and prematurity (interaction-term p value < 0.05).

Conclusion: In this cohort, hormone concentrations varied by DM and prematurity. Early alterations in energy metabolism hormones may reflect changes in developmental programming which persist in the early postnatal period.

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妊娠期暴露于糖尿病后第一周婴儿脂肪因子浓度的变化。

目的：探讨新生儿能量代谢激素在产后第一周的变化。研究设计：在足月和早产儿的前瞻性队列中，在出生后第一周收集脐带血和婴儿血液中测量瘦素、脂联素、胰岛素、抵抗素和胃饥饿素的浓度。每种激素随时间的变化使用线性混合效应回归建模。结果：106例婴儿中，65例（61%）早产，44例（42%）妊娠期暴露于糖尿病（DM）。糖尿病组瘦素[组间差异β 2.5 (95%CI: 1.72-3.70)]、抵抗素[β 1.5 (95%CI:1.14, 1.92)]和胃饥饿素[β 0.49] [95%CI: 0.32-0.76)]高于非糖尿病组。早产儿的脂联素较足月组低[β 0.80 (95%CI: 0.67-0.96)]。胰岛素随糖尿病和早产而变化（相互作用项p值）结论：在本队列中，激素浓度随糖尿病和早产而变化。能量代谢激素的早期改变可能反映了发育程序的变化，这种变化在出生后早期持续存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.