New polyketides from the mangrove-associated endophytic fungus Phomopsis sp. DHS-11.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-03-24 DOI:10.1080/10286020.2025.2482069

Zhi-Kai Guo, Bi-Ting Chen, Dan-Dan Chen, Xiao-Ling Deng, Jing Xu

引用次数: 0

Abstract

Chemical investigation of the mangrove-derived fungus Phomopsis sp. DHS-11 led to the isolation of three new pyrone derivatives (1-3), and a new natural product (4). Their structures were identified by NMR spectroscopy and mass spectrometry. The configurations for the new pyrone derivatives were tentatively solved by comparison of ¹³C NMR data and analysis of the coupling constants and NOESY correlations. Compounds 2 and 3 exhibited significant cytotoxicity against HepG2 with IC₅₀ values of 4.66 ± 0.35 µM and 6.07 ± 0.48 µM, respectively. Compound 3 showed moderate cytotoxicity against Hela cells with IC₅₀ value of 20.2 ± 4.93 µM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.