Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-03-20 DOI:10.1016/j.jad.2025.03.112

Xiang Li , Xiaojun Wang , Linping Zhu , Jianqun Liu , Jianyi Wang , Xiaochun Chen

{"title":"Exploring the association between urticaria subtypes, anxiety, and depression and potential role of gut microbiota","authors":"Xiang Li , Xiaojun Wang , Linping Zhu , Jianqun Liu , Jianyi Wang , Xiaochun Chen","doi":"10.1016/j.jad.2025.03.112","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><div>In observational studies, the causal relationship between urticaria and the risk of psychiatric disorders (anxiety and depression) remains inconclusive. Furthermore, there is growing evidence that gut microbiota (GM) contributes to the pathogenesis of urticaria. This study aimed to assess the causal relationships between the genetically predicted urticaria subtypes and psychiatric disorders and further examined the role of GM in influencing the risk of these urticaria subtypes.</div></div><div><h3>Methods</h3><div>We conducted a meta-analysis of observational studies identified from four databases to evaluate the associations between urticaria, anxiety, and depression over the past decade. In addition, we estimated the genetic correlation and causality between genetically predicted urticaria subtypes and psychiatric disorders using linkage disequilibrium score regression and Mendelian Randomization (MR) analyses. Finally, univariable two-sample MR and multivariable MR analyses were employed to evaluate the combined and independent effects of GM from two datasets on urticaria subtypes associated with psychiatric disorders.</div></div><div><h3>Results</h3><div>Thirteen observational studies comprising 7321 participants were included in the meta-analysis. There was a positive association between urticaria and anxiety risk (<em>n</em> = 13, OR: 3.96; 95%CI: 2.90–5.41) as well as depression risk (<em>n</em> = 12, OR: 3.03; 95%CI: 2.30–4.01). The MR results indicated that idiopathic urticaria increased the risk of anxiety (OR = 1.14; 95%CI = 1.01–1.28; <em>P</em> = 3.31 × 10<sup>−2</sup>), while allergic urticaria increased the risk of major depressive disorder (OR = 1.07; 95%CI = 1.02–1.13; <em>P</em> = 6.65 × 10<sup>−3</sup>). Our analysis identified nineteen gut bacterial taxa that were causally associated with idiopathic and allergic urticaria. Notably, <em>Intestinibacter</em> and <em>Victivallales</em> were strongly associated with an increased risk of allergic urticaria, even after accounting for the effect of smoking or alcohol consumption in the multivariable MR analysis. <em>FamilyXIIIAD3011group</em> and <em>Bacteroides vulgatus</em> were found to exert protective roles in idiopathic urticaria.</div></div><div><h3>Conclusions</h3><div>The study provides evidence for the association between urticaria subtypes and psychiatric disorders, complementing existing observational studies. In addition, our study implies the involvement of gut microbiota in idiopathic and allergic urticaria. However, the specific mechanisms of bacterial action remain to be clarified.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"380 ","pages":"Pages 181-190"},"PeriodicalIF":4.9000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032725004604","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aims

In observational studies, the causal relationship between urticaria and the risk of psychiatric disorders (anxiety and depression) remains inconclusive. Furthermore, there is growing evidence that gut microbiota (GM) contributes to the pathogenesis of urticaria. This study aimed to assess the causal relationships between the genetically predicted urticaria subtypes and psychiatric disorders and further examined the role of GM in influencing the risk of these urticaria subtypes.

Methods

We conducted a meta-analysis of observational studies identified from four databases to evaluate the associations between urticaria, anxiety, and depression over the past decade. In addition, we estimated the genetic correlation and causality between genetically predicted urticaria subtypes and psychiatric disorders using linkage disequilibrium score regression and Mendelian Randomization (MR) analyses. Finally, univariable two-sample MR and multivariable MR analyses were employed to evaluate the combined and independent effects of GM from two datasets on urticaria subtypes associated with psychiatric disorders.

Results

Thirteen observational studies comprising 7321 participants were included in the meta-analysis. There was a positive association between urticaria and anxiety risk (n = 13, OR: 3.96; 95%CI: 2.90–5.41) as well as depression risk (n = 12, OR: 3.03; 95%CI: 2.30–4.01). The MR results indicated that idiopathic urticaria increased the risk of anxiety (OR = 1.14; 95%CI = 1.01–1.28; P = 3.31 × 10⁻²), while allergic urticaria increased the risk of major depressive disorder (OR = 1.07; 95%CI = 1.02–1.13; P = 6.65 × 10⁻³). Our analysis identified nineteen gut bacterial taxa that were causally associated with idiopathic and allergic urticaria. Notably, Intestinibacter and Victivallales were strongly associated with an increased risk of allergic urticaria, even after accounting for the effect of smoking or alcohol consumption in the multivariable MR analysis. FamilyXIIIAD3011group and Bacteroides vulgatus were found to exert protective roles in idiopathic urticaria.

Conclusions

The study provides evidence for the association between urticaria subtypes and psychiatric disorders, complementing existing observational studies. In addition, our study implies the involvement of gut microbiota in idiopathic and allergic urticaria. However, the specific mechanisms of bacterial action remain to be clarified.

查看原文本刊更多论文

目的：在观察性研究中，荨麻疹与精神疾病（焦虑症和抑郁症）风险之间的因果关系仍无定论。此外，越来越多的证据表明，肠道微生物群（GM）是荨麻疹的发病机制之一。本研究旨在评估基因预测的荨麻疹亚型与精神障碍之间的因果关系，并进一步研究肠道微生物群在影响这些荨麻疹亚型风险中的作用：我们对四个数据库中的观察性研究进行了荟萃分析，以评估过去十年间荨麻疹、焦虑和抑郁之间的关联。此外，我们还利用连锁不平衡得分回归和孟德尔随机化（MR）分析，估计了遗传预测的荨麻疹亚型与精神疾病之间的遗传相关性和因果关系。最后，采用单变量双样本 MR 分析和多变量 MR 分析，评估了两个数据集中 GM 对与精神疾病相关的荨麻疹亚型的综合和独立影响：荟萃分析纳入了13项观察性研究，共有7321名参与者。荨麻疹与焦虑风险（n = 13，OR：3.96；95%CI：2.90-5.41）和抑郁风险（n = 12，OR：3.03；95%CI：2.30-4.01）之间存在正相关。MR结果表明，特发性荨麻疹会增加焦虑症的风险（OR = 1.14；95%CI = 1.01-1.28；P = 3.31 × 10-2），而过敏性荨麻疹会增加重度抑郁症的风险（OR = 1.07；95%CI = 1.02-1.13；P = 6.65 × 10-3）。我们的分析发现，19 个肠道细菌类群与特发性和过敏性荨麻疹有因果关系。值得注意的是，肠杆菌和Victivallales与过敏性荨麻疹风险的增加密切相关，即使在多变量MR分析中考虑了吸烟或饮酒的影响。在特发性荨麻疹中，XIIIAD3011group 家族和 Bacteroides vulgatus 发挥着保护作用：本研究为荨麻疹亚型与精神障碍之间的关联提供了证据，补充了现有的观察性研究。此外，我们的研究还暗示肠道微生物群参与了特发性和过敏性荨麻疹的发病。然而，细菌作用的具体机制仍有待明确。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.