{"title":"Imaging neuroglia.","authors":"Janine Doorduin","doi":"10.1016/B978-0-443-19104-6.00016-4","DOIUrl":null,"url":null,"abstract":"<p><p>Imaging can help us understand the role neuroglia plays in health and during the course of neurologic disorders. In vivo microscopy has had a great impact on our understanding of how neuroglia behaves during health and disease. While initially the technique was hindered by the limited penetration depth in brain tissue, recent advancements lead to increasing possibilities for imaging of deeper brain structures, even at super-resolution. Unfortunately, in vivo microscopy cannot be applied in a clinical setting and thus cannot be used to study neuroglia in patient populations. However, noninvasive imaging techniques like positron emission tomography (PET) and magnetic resonance imaging (MRI) can. PET has provided valuable information on the involvement of neuroglia in neurologic disorders. To more specifically image microglia and astrocytes, many new PET biomarkers have been defined for which PET tracers are continuously developed, evaluated, and improved. A cell-type specific PET tracer with favorable imaging characteristics can have a huge impact on neuroglia research. While being less sensitive than PET, MRI is a more accessible imaging technique. Initially, only general neuroinflammation processes could be imaged with MRI, but newly developed methods and sequences allow for increasing cell-type specificity. Overall, while each imaging method comes with limitations, improvements are continuously made, all with the aim to truly understand the role that neuroglia play in health and disease.</p>","PeriodicalId":12907,"journal":{"name":"Handbook of clinical neurology","volume":"209 ","pages":"277-291"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Handbook of clinical neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/B978-0-443-19104-6.00016-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Imaging can help us understand the role neuroglia plays in health and during the course of neurologic disorders. In vivo microscopy has had a great impact on our understanding of how neuroglia behaves during health and disease. While initially the technique was hindered by the limited penetration depth in brain tissue, recent advancements lead to increasing possibilities for imaging of deeper brain structures, even at super-resolution. Unfortunately, in vivo microscopy cannot be applied in a clinical setting and thus cannot be used to study neuroglia in patient populations. However, noninvasive imaging techniques like positron emission tomography (PET) and magnetic resonance imaging (MRI) can. PET has provided valuable information on the involvement of neuroglia in neurologic disorders. To more specifically image microglia and astrocytes, many new PET biomarkers have been defined for which PET tracers are continuously developed, evaluated, and improved. A cell-type specific PET tracer with favorable imaging characteristics can have a huge impact on neuroglia research. While being less sensitive than PET, MRI is a more accessible imaging technique. Initially, only general neuroinflammation processes could be imaged with MRI, but newly developed methods and sequences allow for increasing cell-type specificity. Overall, while each imaging method comes with limitations, improvements are continuously made, all with the aim to truly understand the role that neuroglia play in health and disease.
期刊介绍：
The Handbook of Clinical Neurology (HCN) was originally conceived and edited by Pierre Vinken and George Bruyn as a prestigious, multivolume reference work that would cover all the disorders encountered by clinicians and researchers engaged in neurology and allied fields. The first series of the Handbook (Volumes 1-44) was published between 1968 and 1982 and was followed by a second series (Volumes 45-78), guided by the same editors, which concluded in 2002. By that time, the Handbook had come to represent one of the largest scientific works ever published. In 2002, Professors Michael J. Aminoff, François Boller, and Dick F. Swaab took on the responsibility of supervising the third (current) series, the first volumes of which published in 2003. They have designed this series to encompass both clinical neurology and also the basic and clinical neurosciences that are its underpinning. Given the enormity and complexity of the accumulating literature, it is almost impossible to keep abreast of developments in the field, thus providing the raison d''être for the series. The series will thus appeal to clinicians and investigators alike, providing to each an added dimension. Now, more than 140 volumes after it began, the Handbook of Clinical Neurology series has an unparalleled reputation for providing the latest information on fundamental research on the operation of the nervous system in health and disease, comprehensive clinical information on neurological and related disorders, and up-to-date treatment protocols.
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