Piezo2 expressed in GP: Potential therapeutic target of atrial fibrillation.

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart rhythm Pub Date : 2025-03-20 DOI:10.1016/j.hrthm.2025.03.1964

Xujun Li, Tianyou Xu, Yuhong Wang, Zhipeng Hu, Shoupeng Duan, Chen Peng, Saiting Xu, Chengzhe Liu, Rui Li, Qiang Deng, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu

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引用次数: 0

Abstract

Background: Atrial fibrillation (AF) is closely linked to autonomic nervous system activity, with activation of the cardiac ganglionated plexus (GP) often presents in AF. Piezo, a mechanosensitive ion channel, plays a pivotal role in neuronal modulation. However, its involvement in the GP and AF remains poorly understood.

Objective: This study investigates the expression of Piezo2 in GP and its potential role in AF.

Methods: GP tissues were collected from patients undergoing cardiac transplantation, and Piezos expression levels were assessed. Rapid atrial pacing (RAP) was performed in a large animal model to induce AF, and Piezos expression in GP tissues was also evaluated. Piezo2 knockdown in GP was achieved via adeno-associated virus in animals subjected to RAP. Atrial electrophysiological parameters, AF inducibility, neural activity and GP function, were subsequently analyzed. RNA sequencing was employed to elucidate underlying mechanisms.

Results: In the AF group and in people with higher left atrial pressure, Piezo2 expression was increased in the GP. Knockdown of Piezo2 in GP impaired GP function and neural activity, thereby decreasing AF susceptibility. RNA-seq analysis revealed significant down-regulation of the Notch signaling pathway.

Conclusions: These findings suggest that Piezo2 expressed in GP may serve as a novel therapeutic target for the treatment of AF.

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来源期刊

Heart rhythm 医学-心血管系统

CiteScore

10.50

自引率

5.50%

发文量

1465

审稿时长

24 days

期刊介绍： HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability. HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community. The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.