The Potential of Nano-Formulated Natural Drugs in Melanoma Treatment: A Review of Pharmacological Efficacy and Mechanistic Insights.

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S505394

Bowen Wang, Yinan Wang

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引用次数: 0

Abstract

Melanoma is a very aggressive skin cancer; its treatment bears great challenges, hence the interest in new therapeutic approaches is growing. In this review, potential nano-formulated natural drugs from plants such as Ginseng, Pistacia lentiscus, Amaranthus hypochondriacus, and Cannabis sativa in the treatment of melanoma are discussed. We discuss various characteristics of nanoformulations, including liposomes and nanoemulsions, with respect to their ability in enhancing drug delivery and bioavailability. Key mechanisms of action including reactive oxygen species modulation, apoptotic signaling induction, immune modulation through TLR4/MyD88, and inhibition of angiogenesis by VEGF pathways are discussed. Although these natural nanoformulations show promise in improving therapeutic outcomes, challenges related to their clinical application and safety persist. Further research is warranted to fully explore how this novel approach can best be utilized against melanoma.

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纳米配方天然药物在黑色素瘤治疗中的潜力：药理学疗效和机制见解的综述。

黑色素瘤是一种侵袭性很强的皮肤癌；它的治疗面临着巨大的挑战，因此对新治疗方法的兴趣正在增长。本文综述了人参、黄连木、苋属植物、大麻等植物纳米制剂治疗黑色素瘤的潜力。我们讨论了纳米制剂的各种特性，包括脂质体和纳米乳液，以及它们在增强药物传递和生物利用度方面的能力。主要的作用机制包括活性氧调节，凋亡信号诱导，通过TLR4/MyD88进行免疫调节，以及通过VEGF途径抑制血管生成。尽管这些天然纳米制剂有望改善治疗效果，但与临床应用和安全性相关的挑战仍然存在。进一步的研究需要充分探索这种新方法如何最好地用于治疗黑色素瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.