Sex differences in pulmonary arterial hypertension: Insights from the FOCUS-PAH registry

IF 3.2 2区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Matteo Pagnesi , Mauro Riccardi , Giulio Savonitto , Pietro Ameri , Simonetta Monti , Mauro Driussi , Piero Gentile , Claudia Specchia , Chiara Oriecuia , Marianna Adamo , Matteo Toma , Alberto Giannoni , Emma Di Poi , Luciana D'Angelo , Valentina Colombo , Veronica Vecchiato , Edoardo Airo , Massimo Imazio , Andrea Garascia , Gianfranco Sinagra , Carlo Mario Lombardi
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引用次数: 0

Abstract

Background

Despite the higher incidence of pulmonary arterial hypertension (PAH) in women, sex differences in terms of clinical presentation and prognosis are still uncertain. We assess the impact of sex in patients with PAH.

Methods

Sex differences were evaluated in the multicenter FOCUS-PAH registry, that included patients diagnosed with PAH at 7 tertiary care centers between 2001 and 2022. Patients' characteristics and outcomes were compared in men vs. women, and factors independently associated with long-term outcomes were assessed. The primary endpoint was overall survival.

Results

Among 410 included patients, 273 (66.6 %) were women and 137 (33.4 %) were men. Despite similar age, men had more cardio-renal-metabolic comorbidities and history of HIV infection, whereas women had more connective tissue disorders and scleroderma, and worse functional capacity. Dual therapy was more commonly prescribed in women (39.9 % vs. 27.0 %). At multivariable Cox regression analysis, female sex was independently associated with a lower risk of all-cause mortality (adjusted hazard ratio 0.60, 95 % confidence interval 0.38–0.95, p = 0.031). Age, European Society of Cardiology (ESC) / European Respiratory Society (ERS) risk score, glomerular filtration rate and scleroderma were independently associated with long-term mortality in women, whereas only age and ESC/ERS risk score independently predicted this endpoint in men.

Conclusions

In this real-world registry, women represented 2 out of 3 patients with PAH and female sex was independently associated with a lower risk of mortality. There were differences in the variables associated with long-term mortality between sexes, suggesting that individualized approach to risk stratification should also include sex.
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来源期刊
International journal of cardiology
International journal of cardiology 医学-心血管系统
CiteScore
6.80
自引率
5.70%
发文量
758
审稿时长
44 days
期刊介绍: The International Journal of Cardiology is devoted to cardiology in the broadest sense. Both basic research and clinical papers can be submitted. The journal serves the interest of both practicing clinicians and researchers. In addition to original papers, we are launching a range of new manuscript types, including Consensus and Position Papers, Systematic Reviews, Meta-analyses, and Short communications. Case reports are no longer acceptable. Controversial techniques, issues on health policy and social medicine are discussed and serve as useful tools for encouraging debate.
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