Efficacy of combined non-invasive brain stimulation and robot-assisted gait training on lower extremity recovery post-stroke: a systematic review and meta-analysis of randomized controlled trials.
Jiaoyun Wang, Huihuang Zhang, Jiani Ma, Lei Gu, Xiang Li
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引用次数: 0
Abstract
Background: Lower extremity dysfunction post-stroke significantly impedes patient independence and quality of life. Non-invasive brain stimulation (NIBS) and robot-assisted gait training (RAGT) have individually shown promising outcomes in gait recovery. However, the synergistic efficacy of non-invasive brain stimulation combined with robot-assisted gait training remains uncertain. This systematic review and meta-analysis aim to evaluate the combined therapy's effectiveness on gait improvement and related motor functions in stroke patients.
Methods: Following PRISMA guidelines, a comprehensive search was conducted to identify randomized controlled trials (RCTs) published up to September 2024. The primary outcome was assessed using the 6-min walk test (6MWT), with secondary outcomes examining assessed using the Functional Ambulation Category (FAC); the Motion Index (MI) to analyze exercise intensity; the Modified Ashworth Scale (MAS) to assess spasticity; and spatiotemporal gait parameters (SPG).
Results: Six randomized controlled trials involving 191 stroke patients were included. Meta-analysis revealed that combined non-invasive brain stimulation and robot-assisted gait training significantly improved the 6-min walk test scores (mean difference [MD] = 21.81, 95% CI = 0.03-43.59), though effects on strength, activity participation, spasticity, and coordination were non-significant.
Conclusion: Non-invasive brain stimulation combined with robot-assisted gait training shows potential in enhancing gait function but provides limited additional benefits for other motor functions. This combined approach may serve as an effective rehabilitation strategy for post-stroke gait recovery, warranting further large-scale studies to refine intervention protocols.
期刊介绍：
The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.
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