{"title":"Is extra virgin olive oil a promising remedy for reducing the impact of postmenopausal osteoporosis? An experimental study.","authors":"El-Sayed El-Shafaey, Eman Ali, Magda Elkomy, Mohamed Abdo Rizk, Saleh Altuwaijri, Saleh Albarrak","doi":"10.3389/fvets.2025.1555779","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Osteoporosis, particularly postmenopausal osteoporosis, is a significant global health challenge with limited treatment options due to severe side effects associated with the long-term use of conventional therapies. Therefore, this study aims to provide a potentially novel therapeutic approach by examining olive oil's effects on bone mineral density (BMD), biochemical markers, biomechanical properties, and histopathological changes in an ovariectomized (OVX) rat model.</p><p><strong>Methods: </strong>In this study, Twenty-four 6-month-old female Wistar rats were randomly allocated into four equal groups (<i>n</i> = 6 rats, for each group): control group, rats given 1mL/100g olive oil, ovariectomized rats (OVX-group), and OVX rats treated with olive oil. The femoral bone mineral density (BMD), biochemical parameters, biomechanical properties, and histopathological features were studied.</p><p><strong>Results: </strong>After 3 months of extra virgin olive oil treatment, there were significant improvements in the different estimated parameters. This was demonstrated by preventing the changes in bone remodeling and BMD, improving the hormonal changes, oxidant/antioxidant imbalance, and abnormal levels of pro-inflammatory cytokines associated with OVX-induced osteoporosis. In addition, there was a marked improvement in the histological architecture of the cancellous and cortical bone appearance.</p><p><strong>Conclusion: </strong>Olive oil dietary intake effectively reduces the impact of osteoporosis induced by ovariectomy in rats, suggesting a potentially feasible treatment option for postmenopausal osteoporosis that benefits bone architecture without any detrimental side effects on women's health.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1555779"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927216/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Veterinary Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fvets.2025.1555779","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Osteoporosis, particularly postmenopausal osteoporosis, is a significant global health challenge with limited treatment options due to severe side effects associated with the long-term use of conventional therapies. Therefore, this study aims to provide a potentially novel therapeutic approach by examining olive oil's effects on bone mineral density (BMD), biochemical markers, biomechanical properties, and histopathological changes in an ovariectomized (OVX) rat model.
Methods: In this study, Twenty-four 6-month-old female Wistar rats were randomly allocated into four equal groups (n = 6 rats, for each group): control group, rats given 1mL/100g olive oil, ovariectomized rats (OVX-group), and OVX rats treated with olive oil. The femoral bone mineral density (BMD), biochemical parameters, biomechanical properties, and histopathological features were studied.
Results: After 3 months of extra virgin olive oil treatment, there were significant improvements in the different estimated parameters. This was demonstrated by preventing the changes in bone remodeling and BMD, improving the hormonal changes, oxidant/antioxidant imbalance, and abnormal levels of pro-inflammatory cytokines associated with OVX-induced osteoporosis. In addition, there was a marked improvement in the histological architecture of the cancellous and cortical bone appearance.
Conclusion: Olive oil dietary intake effectively reduces the impact of osteoporosis induced by ovariectomy in rats, suggesting a potentially feasible treatment option for postmenopausal osteoporosis that benefits bone architecture without any detrimental side effects on women's health.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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