Melatonin: The potential avenues in dentistry.

Q2 Pharmacology, Toxicology and Pharmaceutics
F1000Research Pub Date : 2025-01-14 eCollection Date: 2025-01-01 DOI:10.12688/f1000research.159942.1
Dr Sanidhya S, Deepa Kamath, Aradhya Sinha, Diya Kamath
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引用次数: 0

Abstract

Melatonin, the "sleep hormone," shows significant promise in dentistry owing to its antioxidant, anti-inflammatory, and immunomodulatory properties. It is beneficial for treating periodontal disorders and aiding osseointegration of dental implants. Additionally, melatonin helps to manage dental anxiety, offering an alternative to traditional sedatives. Periodontal disease is orchestrated by bacterial plaques along with an exaggerated immune-inflammatory host response. Treatment of periodontitis not only involves the removal of plaque, but also aims to minimize the cytokine load and control the reactive oxygen species burden in the tissues, which would re-establish a healthy periodontium and a balanced bone metabolism. Melatonin is known to exert beneficial effects, such as regulation of circadian rhythm, bone remodeling, and antimicrobial effects. Recent studies have demonstrated the successful use of melatonin as an adjunct to mechanical debridement for the treatment of periodontal disease. Its various uses include systemic administration of melatonin after one-stage full-mouth Non-Surgical Periodontal Therapy in healthy subjects as well as patients. This article provides a summary of the various clinical applications of melatonin, describing its mechanism of action, uses, and potential avenues for future research in dentistry.

褪黑素:在牙科的潜在途径。
褪黑素,即“睡眠激素”,由于其抗氧化、抗炎和免疫调节的特性,在牙科领域显示出巨大的前景。它有利于治疗牙周疾病和促进种植体的骨整合。此外,褪黑素有助于控制牙齿焦虑,为传统镇静剂提供了另一种选择。牙周病是由细菌斑块和过度的免疫炎症宿主反应精心策划的。牙周炎的治疗不仅包括清除牙菌斑,还包括减少细胞因子负荷和控制组织中的活性氧负荷,从而重建健康的牙周组织和平衡的骨代谢。众所周知,褪黑素具有有益的作用,如调节昼夜节律、骨骼重塑和抗菌作用。最近的研究已经证明,褪黑激素作为机械清创治疗牙周病的辅助手段是成功的。它的各种用途包括在健康受试者和患者的一期全口非手术牙周治疗后全身给药褪黑素。本文概述了褪黑素的各种临床应用,描述了其作用机制,用途,以及未来牙科研究的潜在途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
F1000Research
F1000Research Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
5.00
自引率
0.00%
发文量
1646
审稿时长
1 weeks
期刊介绍: F1000Research publishes articles and other research outputs reporting basic scientific, scholarly, translational and clinical research across the physical and life sciences, engineering, medicine, social sciences and humanities. F1000Research is a scholarly publication platform set up for the scientific, scholarly and medical research community; each article has at least one author who is a qualified researcher, scholar or clinician actively working in their speciality and who has made a key contribution to the article. Articles must be original (not duplications). All research is suitable irrespective of the perceived level of interest or novelty; we welcome confirmatory and negative results, as well as null studies. F1000Research publishes different type of research, including clinical trials, systematic reviews, software tools, method articles, and many others. Reviews and Opinion articles providing a balanced and comprehensive overview of the latest discoveries in a particular field, or presenting a personal perspective on recent developments, are also welcome. See the full list of article types we accept for more information.
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