Causal effects of allergic diseases on the risk of myopia: a two-sample Mendelian randomization study.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Eye Pub Date : 2025-03-22 DOI:10.1038/s41433-025-03749-7

Ximin Wei, Weitao Li, Rong Liu

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引用次数: 0

Abstract

Objective: Myopia is a common eye disease, and the effect of allergic diseases on myopia is unclear. This study was to explore the causal relationship between allergic diseases and myopia risk through a two-sample Mendelian randomization (MR) analysis.

Materials and methods: Genetic variants related to allergic diseases (allergic conjunctivitis, atopic dermatitis, allergic rhinitis, and asthma) and immunoglobulin E and myopia were extracted from the MRC-IEU Open genome-wide association studies (GWAS) project. The results of MR were based on the inverse-variance weighted (IVW) analysis. The odds ratio (OR) and 95% confidence interval (CI) were used to report causal relationships.

Results: Genetically predicted asthma [IVW: OR = 1.233 (95% CI: 1.043-1.456), P = 0.0140] and higher immunoglobulin E levels [IVW: OR = 1.136 (95% CI: 1.020-1.265), P = 0.0207] increased the risk of myopia. There was no significant causal relationship between allergic conjunctivitis (IVW: P = 0.2916), atopic dermatitis (IVW: P = 0.3168), and allergic rhinitis (IVW: P = 0.8297) and risk of myopia. Further analysis revealed that the causal correlation of immunoglobulin E levels with myopia risk was caused by outliers.

Conclusions: Genetically predicted asthma increased the risk of myopia.

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过敏性疾病对近视风险的因果影响：一项双样本孟德尔随机研究。

目的：近视是一种常见的眼病，过敏性疾病对近视的影响尚不清楚。本研究旨在通过双样本孟德尔随机化（MR）分析，探讨过敏性疾病与近视风险之间的因果关系。材料和方法：从MRC-IEU开放全基因组关联研究（GWAS）项目中提取与变应性疾病（变应性结膜炎、特应性皮炎、过敏性鼻炎和哮喘）以及免疫球蛋白E和近视相关的遗传变异。MR结果基于逆方差加权（IVW）分析。比值比（OR）和95%置信区间（CI）用于报告因果关系。结果：遗传预测哮喘[IVW: OR = 1.233 (95% CI: 1.043-1.456), P = 0.0140]和较高的免疫球蛋白E水平[IVW: OR = 1.136 (95% CI: 1.020-1.265), P = 0.0207]增加近视的风险。变应性结膜炎（IVW: P = 0.2916）、特应性皮炎（IVW: P = 0.3168）、变应性鼻炎（IVW: P = 0.8297）与近视风险无显著因果关系。进一步分析发现，免疫球蛋白E水平与近视风险的因果关系是由异常值引起的。结论：基因预测哮喘会增加近视的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.