Particulate Versus Cross-Linked Collagenated Bone Substitutes for Guided Bone Regeneration: A Randomized Controlled Trial

IF 5.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Implants Research Pub Date : 2025-03-24 DOI:10.1111/clr.14433

Ji-Young Jung, Seung-Hyun Park, Kwan-Jung Kim, Kyung-A Ko, Dong-Woon Lee, Jung-Seok Lee

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引用次数: 0

Abstract

Aim

To compare the dimensional outcomes of horizontal augmentation with the retentive-flap technique using particulate and cross-linked collagenated bone substitutes.

Materials and Methods

This two-centre, two-arm randomized clinical trial investigated 69 subjects: 34 in the particulate group and 35 in the collagenated group. Patients were randomly assigned to receive single implant placement with simultaneous guided bone regeneration (GBR) using either particulate deproteinized porcine bone material (DPBM) or cross-linked collagenated DPBM. Quantitative evaluations were conducted for horizontal width, augmented area, and augmented volume in both hard and soft tissue dimensions.

Results

Immediately after surgery, the collagenated group exhibited higher hard tissue dimensions in terms of horizontal width and augmented area. After 4 months, the difference between the two groups decreased to a non-significant level, mainly attributable to the high shrinkage rate of the collagenated group (32.32 [20.79] %) compared to the particulate group (19.90 [14.33] %). No significant difference was observed regarding the soft tissue contour analyses between the two groups after 4 months.

Conclusions

There were no significant differences between cross-linked collagenated and particulated DPBMs regarding the dimensional outcomes of horizontal augmentation with the retentive-flap technique. The high resorption rate of the collagenated bone substitute negates its initial superiority in both radiographic and soft tissue dimensions (no. KCT0005348).

Abstract Image

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颗粒与交联胶原骨替代物引导骨再生：一项随机对照试验。

目的：比较颗粒骨和交联胶原骨替代物的水平增强与保留瓣技术的尺寸效果。材料与方法：这项双中心、双臂随机临床试验调查了69名受试者：颗粒组34名，胶原组35名。患者被随机分配接受单次植入并同时引导骨再生（GBR），使用颗粒脱蛋白猪骨材料（DPBM）或交联胶原DPBM。对水平宽度、增强面积和增强体积在硬组织和软组织维度上进行了定量评估。结果：术后即刻，胶原组在水平宽度和增强面积方面表现出更高的硬组织尺寸。4个月后，两组之间的差异下降到不显著水平，主要原因是胶原组的收缩率（32.32[20.79]%）高于颗粒组（19.90[14.33]%）。4个月后，两组软组织轮廓分析无明显差异。结论：在保留瓣技术水平增强的尺寸结果方面，交联胶原和颗粒DPBMs之间没有显著差异。胶原骨替代物的高吸收率否定了其在放射学和软组织方面的最初优势。KCT0005348)。

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来源期刊

Clinical Oral Implants Research 医学-工程：生物医学

CiteScore

7.70

自引率

11.60%

发文量

149

审稿时长

3 months

期刊介绍： Clinical Oral Implants Research conveys scientific progress in the field of implant dentistry and its related areas to clinicians, teachers and researchers concerned with the application of this information for the benefit of patients in need of oral implants. The journal addresses itself to clinicians, general practitioners, periodontists, oral and maxillofacial surgeons and prosthodontists, as well as to teachers, academicians and scholars involved in the education of professionals and in the scientific promotion of the field of implant dentistry.