Assessment of arterial stiffness in patients with diabetic retinopathy: A systematic review and meta-analysis

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2025-03-22 DOI:10.1016/j.diabres.2025.112123

Dimitrios Kazantzis , Konstantinos Papathanasiou , Genovefa Machairoudia , Panagiotis Theodossiadis , Irini Chatziralli

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引用次数: 0

Abstract

Background

Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). A number of studies have investigated if patients with diabetic retinopathy present altered arterial stiffness compared to diabetic individuals without retinopathy.

Objectives

To compare arterial stiffness parameters in participants with diabetic retinopathy (DR) compared to participants with diabetes without retinopathy.

Methods

Medline and Scopus were searched for published articles comparing indices of arterial stiffness in participants with DR and in diabetic participants without retinopathy. Standardized Mean Difference (SMD) with 95% confidence interval (CI) was calculated for the comparisons. The study protocol was registered with PROSPERO with registration ID: CRD42023482577.

Results:

The meta-analysis analyzed 3 arterial stiffness parameters brachial ankle PWV, carotid-femoral PWV and augmentation index (AI). 8 studies were included in the analysis of brachial ankle PWV, 4 in the analysis of carotid-femoral PWV and 4 in the analysis of the augmentation index. Brachial ankle PWV, carotid-femoral PWV and augmentation index were found to be increased in participants with DR compared to diabetic participants without DR (SMD = 0.59, 95 %CI = 0.40–0.79, P < 0.00001, I² = 89 %, SMD = 0.86, 95 %CI = 0.55–1.18P < 0.00001, I² = 91 % and SMD = 0.23, 95 %CI = 0.13–0.32, P < 0.00001, I² = 0 %, respectively).

Conclusion

Diabetic participants with DR exhibit increased arterial stiffness compared to diabetic participants without DR.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.