Zhenjun Yu, Jie Chen, Mengdie Chen, Qiaoling Pan, Yaojian Shao, Xiaolong Jin, Chaohui Wang, Yuetao Zhang, Gang Lin, Ping Feng, Xiaosheng Teng
{"title":"Analysis between Helicobacter pylori infection and hepatobiliary diseases.","authors":"Zhenjun Yu, Jie Chen, Mengdie Chen, Qiaoling Pan, Yaojian Shao, Xiaolong Jin, Chaohui Wang, Yuetao Zhang, Gang Lin, Ping Feng, Xiaosheng Teng","doi":"10.3389/fcimb.2025.1477699","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Helicobacter pylori (<i>H. pylori</i>) represents a significant chronic health concern, affecting approximately half of the global population. While <i>H. pylori</i> infection has been closely linked to numerous extradigestive diseases, the relationship between <i>H. pylori</i> and lesions in the gallbladder and biliary tract remains under debate.</p><p><strong>Method: </strong>We retrospectively collected data from patients who underwent <i>H. pylori</i> tests at the Physical Examination Center of Taizhou Central Hospital (Taizhou University Hospital) between 2018 and 2022. Logistic regression analysis and restricted cubic spline analysis were employed to investigate the correlation between parameters and <i>H. pylori</i>. Additionally, we utilized population data from the National Health and Nutrition Examination Survey (NHANES) database as an external validation cohort.</p><p><strong>Results: </strong>A total of 30,612 patients were included in the training set, with 22,296 (72.8%) belonging to the <i>H. pylori</i> non-infection group and 8,316 (27.2%) to the <i>H. pylori</i> infection group. Compared to the non-infection group, patients in the infection group exhibited a significant decrease in albumin levels and a notable increase in total cholesterol and erythrocyte sedimentation rate levels. Furthermore, the infection group demonstrated significantly higher occurrences of gallbladder cholesterol crystals (6.0%), gallbladder polyps (20.2%), and atherosclerosis (25.6%) compared to the non-infection group, with respective rates of 5.1%, 19.1%, and 21.4% (average p < 0.05). However, no significant differences were observed between the two groups in terms of fatty liver, intrahepatic inflammation, gallstones, or cholecystitis. Additional regression analysis revealed that <i>H. pylori</i>, age, BMI, albumin, and total cholesterol were independent risk factors for the cholesterol crystals and atherosclerosis.</p><p><strong>Conclusion: </strong><i>H. pylori</i> infection is closely associated with the gallbladder cholesterol crystals and atherosclerosis, albeit not with conditions such as fatty liver, gallbladder stones, or cholecystitis. Future research necessitates multi-center, prospective studies to corroborate these findings.</p>","PeriodicalId":12458,"journal":{"name":"Frontiers in Cellular and Infection Microbiology","volume":"15 ","pages":"1477699"},"PeriodicalIF":4.6000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926543/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cellular and Infection Microbiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fcimb.2025.1477699","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Helicobacter pylori (H. pylori) represents a significant chronic health concern, affecting approximately half of the global population. While H. pylori infection has been closely linked to numerous extradigestive diseases, the relationship between H. pylori and lesions in the gallbladder and biliary tract remains under debate.
Method: We retrospectively collected data from patients who underwent H. pylori tests at the Physical Examination Center of Taizhou Central Hospital (Taizhou University Hospital) between 2018 and 2022. Logistic regression analysis and restricted cubic spline analysis were employed to investigate the correlation between parameters and H. pylori. Additionally, we utilized population data from the National Health and Nutrition Examination Survey (NHANES) database as an external validation cohort.
Results: A total of 30,612 patients were included in the training set, with 22,296 (72.8%) belonging to the H. pylori non-infection group and 8,316 (27.2%) to the H. pylori infection group. Compared to the non-infection group, patients in the infection group exhibited a significant decrease in albumin levels and a notable increase in total cholesterol and erythrocyte sedimentation rate levels. Furthermore, the infection group demonstrated significantly higher occurrences of gallbladder cholesterol crystals (6.0%), gallbladder polyps (20.2%), and atherosclerosis (25.6%) compared to the non-infection group, with respective rates of 5.1%, 19.1%, and 21.4% (average p < 0.05). However, no significant differences were observed between the two groups in terms of fatty liver, intrahepatic inflammation, gallstones, or cholecystitis. Additional regression analysis revealed that H. pylori, age, BMI, albumin, and total cholesterol were independent risk factors for the cholesterol crystals and atherosclerosis.
Conclusion: H. pylori infection is closely associated with the gallbladder cholesterol crystals and atherosclerosis, albeit not with conditions such as fatty liver, gallbladder stones, or cholecystitis. Future research necessitates multi-center, prospective studies to corroborate these findings.
期刊介绍：
Frontiers in Cellular and Infection Microbiology is a leading specialty journal, publishing rigorously peer-reviewed research across all pathogenic microorganisms and their interaction with their hosts. Chief Editor Yousef Abu Kwaik, University of Louisville is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
Frontiers in Cellular and Infection Microbiology includes research on bacteria, fungi, parasites, viruses, endosymbionts, prions and all microbial pathogens as well as the microbiota and its effect on health and disease in various hosts. The research approaches include molecular microbiology, cellular microbiology, gene regulation, proteomics, signal transduction, pathogenic evolution, genomics, structural biology, and virulence factors as well as model hosts. Areas of research to counteract infectious agents by the host include the host innate and adaptive immune responses as well as metabolic restrictions to various pathogenic microorganisms, vaccine design and development against various pathogenic microorganisms, and the mechanisms of antibiotic resistance and its countermeasures.
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