Biomarkers in dementia disorders - a narrative review.

IF 1.2 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Danish medical journal Pub Date : 2025-02-21 DOI:10.61409/A09240634

Steen Gregers Hasselbalch

引用次数: 0

Abstract

With the introduction of specific or unspecific biomarkers, the diagnosis of dementia disorders has changed from a purely clinical to a biological construct. This review presents biomarkers for the most common neurodegenerative disorders. Specific biomarkers for misfolded proteins have been developed for Alzheimer's disease and dementia with Lewy bodies. Unspecific biomarkers for neurodegeneration, synaptic dysfunction and neuroinflammation may also be helpful in diagnosing or staging dementia disorders.

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痴呆疾病的生物标志物——叙述性综述。

随着特异性或非特异性生物标志物的引入，痴呆症的诊断已经从纯粹的临床转变为生物学结构。本文综述了最常见的神经退行性疾病的生物标志物。针对阿尔茨海默病和路易小体痴呆的错误折叠蛋白的特异性生物标志物已经被开发出来。神经变性、突触功能障碍和神经炎症的非特异性生物标志物也可能有助于痴呆症的诊断或分期。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Danish medical journal MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content. DMJ will publish the following articles: • Original articles • Protocol articles from large randomized clinical trials • Systematic reviews and meta-analyses • PhD theses from Danish faculties of health sciences • DMSc theses from Danish faculties of health sciences.